Cargando…
A Marine Anthraquinone SZ-685C Overrides Adriamycin-Resistance in Breast Cancer Cells through Suppressing Akt Signaling
Breast cancer remains a major health problem worldwide. While chemotherapy represents an important therapeutic modality against breast cancer, limitations in the clinical use of chemotherapy remain formidable because of chemoresistance. The HER2/PI-3K/Akt pathway has been demonstrated to play a caus...
Autores principales: | , , , , , , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2012
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3366670/ https://www.ncbi.nlm.nih.gov/pubmed/22690138 http://dx.doi.org/10.3390/md10040694 |
_version_ | 1782234758689849344 |
---|---|
author | Zhu, Xun He, Zhenjian Wu, Jueheng Yuan, Jie Wen, Weitao Hu, Yiwen Jiang, Yi Lin, Cuiji Zhang, Qianhui Lin, Min Zhang, Henan Yang, Wan Chen, Hong Zhong, Lili She, Zhigang Chen, Shengping Lin, Yongcheng Li, Mengfeng |
author_facet | Zhu, Xun He, Zhenjian Wu, Jueheng Yuan, Jie Wen, Weitao Hu, Yiwen Jiang, Yi Lin, Cuiji Zhang, Qianhui Lin, Min Zhang, Henan Yang, Wan Chen, Hong Zhong, Lili She, Zhigang Chen, Shengping Lin, Yongcheng Li, Mengfeng |
author_sort | Zhu, Xun |
collection | PubMed |
description | Breast cancer remains a major health problem worldwide. While chemotherapy represents an important therapeutic modality against breast cancer, limitations in the clinical use of chemotherapy remain formidable because of chemoresistance. The HER2/PI-3K/Akt pathway has been demonstrated to play a causal role in conferring a broad chemoresistance in breast cancer cells and thus justified to be a target for enhancing the effects of anti-breast cancer chemotherapies, such as adriamycin (ADR). Agents that can either enhance the effects of chemotherapeutics or overcome chemoresistance are urgently needed for the treatment of breast cancer. In this context, SZ-685C, an agent that has been previously shown, as such, to suppress Akt signaling, is expected to increase the efficacy of chemotherapy. Our current study investigated whether SZ-685C can override chemoresistance through inhibiting Akt signaling in human breast cancer cells. ADR-resistant cells derived from human breast cancer cell lines MCF-7, MCF-7/ADR and MCF-7/Akt, were used as models to test the effects of SZ-685C. We found that SZ-685C suppressed the Akt pathway and induced apoptosis in MCF-7/ADR and MCF-7/Akt cells that are resistant to ADR treatment, leading to antitumor effects both in vitro and in vivo. Our data suggest that use of SZ-685C might represent a potentially promising approach to the treatment of ADR-resistant breast cancer. |
format | Online Article Text |
id | pubmed-3366670 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-33666702012-06-11 A Marine Anthraquinone SZ-685C Overrides Adriamycin-Resistance in Breast Cancer Cells through Suppressing Akt Signaling Zhu, Xun He, Zhenjian Wu, Jueheng Yuan, Jie Wen, Weitao Hu, Yiwen Jiang, Yi Lin, Cuiji Zhang, Qianhui Lin, Min Zhang, Henan Yang, Wan Chen, Hong Zhong, Lili She, Zhigang Chen, Shengping Lin, Yongcheng Li, Mengfeng Mar Drugs Article Breast cancer remains a major health problem worldwide. While chemotherapy represents an important therapeutic modality against breast cancer, limitations in the clinical use of chemotherapy remain formidable because of chemoresistance. The HER2/PI-3K/Akt pathway has been demonstrated to play a causal role in conferring a broad chemoresistance in breast cancer cells and thus justified to be a target for enhancing the effects of anti-breast cancer chemotherapies, such as adriamycin (ADR). Agents that can either enhance the effects of chemotherapeutics or overcome chemoresistance are urgently needed for the treatment of breast cancer. In this context, SZ-685C, an agent that has been previously shown, as such, to suppress Akt signaling, is expected to increase the efficacy of chemotherapy. Our current study investigated whether SZ-685C can override chemoresistance through inhibiting Akt signaling in human breast cancer cells. ADR-resistant cells derived from human breast cancer cell lines MCF-7, MCF-7/ADR and MCF-7/Akt, were used as models to test the effects of SZ-685C. We found that SZ-685C suppressed the Akt pathway and induced apoptosis in MCF-7/ADR and MCF-7/Akt cells that are resistant to ADR treatment, leading to antitumor effects both in vitro and in vivo. Our data suggest that use of SZ-685C might represent a potentially promising approach to the treatment of ADR-resistant breast cancer. MDPI 2012-03-23 /pmc/articles/PMC3366670/ /pubmed/22690138 http://dx.doi.org/10.3390/md10040694 Text en © 2012 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). |
spellingShingle | Article Zhu, Xun He, Zhenjian Wu, Jueheng Yuan, Jie Wen, Weitao Hu, Yiwen Jiang, Yi Lin, Cuiji Zhang, Qianhui Lin, Min Zhang, Henan Yang, Wan Chen, Hong Zhong, Lili She, Zhigang Chen, Shengping Lin, Yongcheng Li, Mengfeng A Marine Anthraquinone SZ-685C Overrides Adriamycin-Resistance in Breast Cancer Cells through Suppressing Akt Signaling |
title | A Marine Anthraquinone SZ-685C Overrides Adriamycin-Resistance in Breast Cancer Cells through Suppressing Akt Signaling |
title_full | A Marine Anthraquinone SZ-685C Overrides Adriamycin-Resistance in Breast Cancer Cells through Suppressing Akt Signaling |
title_fullStr | A Marine Anthraquinone SZ-685C Overrides Adriamycin-Resistance in Breast Cancer Cells through Suppressing Akt Signaling |
title_full_unstemmed | A Marine Anthraquinone SZ-685C Overrides Adriamycin-Resistance in Breast Cancer Cells through Suppressing Akt Signaling |
title_short | A Marine Anthraquinone SZ-685C Overrides Adriamycin-Resistance in Breast Cancer Cells through Suppressing Akt Signaling |
title_sort | marine anthraquinone sz-685c overrides adriamycin-resistance in breast cancer cells through suppressing akt signaling |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3366670/ https://www.ncbi.nlm.nih.gov/pubmed/22690138 http://dx.doi.org/10.3390/md10040694 |
work_keys_str_mv | AT zhuxun amarineanthraquinonesz685coverridesadriamycinresistanceinbreastcancercellsthroughsuppressingaktsignaling AT hezhenjian amarineanthraquinonesz685coverridesadriamycinresistanceinbreastcancercellsthroughsuppressingaktsignaling AT wujueheng amarineanthraquinonesz685coverridesadriamycinresistanceinbreastcancercellsthroughsuppressingaktsignaling AT yuanjie amarineanthraquinonesz685coverridesadriamycinresistanceinbreastcancercellsthroughsuppressingaktsignaling AT wenweitao amarineanthraquinonesz685coverridesadriamycinresistanceinbreastcancercellsthroughsuppressingaktsignaling AT huyiwen amarineanthraquinonesz685coverridesadriamycinresistanceinbreastcancercellsthroughsuppressingaktsignaling AT jiangyi amarineanthraquinonesz685coverridesadriamycinresistanceinbreastcancercellsthroughsuppressingaktsignaling AT lincuiji amarineanthraquinonesz685coverridesadriamycinresistanceinbreastcancercellsthroughsuppressingaktsignaling AT zhangqianhui amarineanthraquinonesz685coverridesadriamycinresistanceinbreastcancercellsthroughsuppressingaktsignaling AT linmin amarineanthraquinonesz685coverridesadriamycinresistanceinbreastcancercellsthroughsuppressingaktsignaling AT zhanghenan amarineanthraquinonesz685coverridesadriamycinresistanceinbreastcancercellsthroughsuppressingaktsignaling AT yangwan amarineanthraquinonesz685coverridesadriamycinresistanceinbreastcancercellsthroughsuppressingaktsignaling AT chenhong amarineanthraquinonesz685coverridesadriamycinresistanceinbreastcancercellsthroughsuppressingaktsignaling AT zhonglili amarineanthraquinonesz685coverridesadriamycinresistanceinbreastcancercellsthroughsuppressingaktsignaling AT shezhigang amarineanthraquinonesz685coverridesadriamycinresistanceinbreastcancercellsthroughsuppressingaktsignaling AT chenshengping amarineanthraquinonesz685coverridesadriamycinresistanceinbreastcancercellsthroughsuppressingaktsignaling AT linyongcheng amarineanthraquinonesz685coverridesadriamycinresistanceinbreastcancercellsthroughsuppressingaktsignaling AT limengfeng amarineanthraquinonesz685coverridesadriamycinresistanceinbreastcancercellsthroughsuppressingaktsignaling AT zhuxun marineanthraquinonesz685coverridesadriamycinresistanceinbreastcancercellsthroughsuppressingaktsignaling AT hezhenjian marineanthraquinonesz685coverridesadriamycinresistanceinbreastcancercellsthroughsuppressingaktsignaling AT wujueheng marineanthraquinonesz685coverridesadriamycinresistanceinbreastcancercellsthroughsuppressingaktsignaling AT yuanjie marineanthraquinonesz685coverridesadriamycinresistanceinbreastcancercellsthroughsuppressingaktsignaling AT wenweitao marineanthraquinonesz685coverridesadriamycinresistanceinbreastcancercellsthroughsuppressingaktsignaling AT huyiwen marineanthraquinonesz685coverridesadriamycinresistanceinbreastcancercellsthroughsuppressingaktsignaling AT jiangyi marineanthraquinonesz685coverridesadriamycinresistanceinbreastcancercellsthroughsuppressingaktsignaling AT lincuiji marineanthraquinonesz685coverridesadriamycinresistanceinbreastcancercellsthroughsuppressingaktsignaling AT zhangqianhui marineanthraquinonesz685coverridesadriamycinresistanceinbreastcancercellsthroughsuppressingaktsignaling AT linmin marineanthraquinonesz685coverridesadriamycinresistanceinbreastcancercellsthroughsuppressingaktsignaling AT zhanghenan marineanthraquinonesz685coverridesadriamycinresistanceinbreastcancercellsthroughsuppressingaktsignaling AT yangwan marineanthraquinonesz685coverridesadriamycinresistanceinbreastcancercellsthroughsuppressingaktsignaling AT chenhong marineanthraquinonesz685coverridesadriamycinresistanceinbreastcancercellsthroughsuppressingaktsignaling AT zhonglili marineanthraquinonesz685coverridesadriamycinresistanceinbreastcancercellsthroughsuppressingaktsignaling AT shezhigang marineanthraquinonesz685coverridesadriamycinresistanceinbreastcancercellsthroughsuppressingaktsignaling AT chenshengping marineanthraquinonesz685coverridesadriamycinresistanceinbreastcancercellsthroughsuppressingaktsignaling AT linyongcheng marineanthraquinonesz685coverridesadriamycinresistanceinbreastcancercellsthroughsuppressingaktsignaling AT limengfeng marineanthraquinonesz685coverridesadriamycinresistanceinbreastcancercellsthroughsuppressingaktsignaling |