Studies on the Synthesis of Derivatives of Marine-Derived Bostrycin and Their Structure-Activity Relationship against Tumor Cells

A series of new derivatives (5–29) of marine-derived bostrycin (1) were synthesized. The in vitro cytotoxic activities of all compounds were evaluated against MCF-7, MDA-MB-435, A549, HepG2, HCT-116 and MCF-10A cells using the MTT method. The compounds 7, 8, 22, 23, 25, 28 and 29 of the total showed...

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Autores principales: Chen, Hong, Zhong, Lili, Long, Yuhua, Li, Jia, Wu, Jueheng, Liu, Lan, Chen, Shengping, Lin, Yongcheng, Li, Mengfeng, Zhu, Xun, She, Zhigang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3366684/
https://www.ncbi.nlm.nih.gov/pubmed/22690152
http://dx.doi.org/10.3390/md10040932
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author Chen, Hong
Zhong, Lili
Long, Yuhua
Li, Jia
Wu, Jueheng
Liu, Lan
Chen, Shengping
Lin, Yongcheng
Li, Mengfeng
Zhu, Xun
She, Zhigang
author_facet Chen, Hong
Zhong, Lili
Long, Yuhua
Li, Jia
Wu, Jueheng
Liu, Lan
Chen, Shengping
Lin, Yongcheng
Li, Mengfeng
Zhu, Xun
She, Zhigang
author_sort Chen, Hong
collection PubMed
description A series of new derivatives (5–29) of marine-derived bostrycin (1) were synthesized. The in vitro cytotoxic activities of all compounds were evaluated against MCF-7, MDA-MB-435, A549, HepG2, HCT-116 and MCF-10A cells using the MTT method. The compounds 7, 8, 22, 23, 25, 28 and 29 of the total showed comparable activity to epirubicin, the positive control, against the tested cancer cell lines. However, these compounds also exhibited cytotoxicity towards MCF-10A cells. The structure-activity relationship (SAR) of bostrycin derivatives was also discussed based on the obtained experimental data.
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spelling pubmed-33666842012-06-11 Studies on the Synthesis of Derivatives of Marine-Derived Bostrycin and Their Structure-Activity Relationship against Tumor Cells Chen, Hong Zhong, Lili Long, Yuhua Li, Jia Wu, Jueheng Liu, Lan Chen, Shengping Lin, Yongcheng Li, Mengfeng Zhu, Xun She, Zhigang Mar Drugs Article A series of new derivatives (5–29) of marine-derived bostrycin (1) were synthesized. The in vitro cytotoxic activities of all compounds were evaluated against MCF-7, MDA-MB-435, A549, HepG2, HCT-116 and MCF-10A cells using the MTT method. The compounds 7, 8, 22, 23, 25, 28 and 29 of the total showed comparable activity to epirubicin, the positive control, against the tested cancer cell lines. However, these compounds also exhibited cytotoxicity towards MCF-10A cells. The structure-activity relationship (SAR) of bostrycin derivatives was also discussed based on the obtained experimental data. MDPI 2012-04-24 /pmc/articles/PMC3366684/ /pubmed/22690152 http://dx.doi.org/10.3390/md10040932 Text en © 2012 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Chen, Hong
Zhong, Lili
Long, Yuhua
Li, Jia
Wu, Jueheng
Liu, Lan
Chen, Shengping
Lin, Yongcheng
Li, Mengfeng
Zhu, Xun
She, Zhigang
Studies on the Synthesis of Derivatives of Marine-Derived Bostrycin and Their Structure-Activity Relationship against Tumor Cells
title Studies on the Synthesis of Derivatives of Marine-Derived Bostrycin and Their Structure-Activity Relationship against Tumor Cells
title_full Studies on the Synthesis of Derivatives of Marine-Derived Bostrycin and Their Structure-Activity Relationship against Tumor Cells
title_fullStr Studies on the Synthesis of Derivatives of Marine-Derived Bostrycin and Their Structure-Activity Relationship against Tumor Cells
title_full_unstemmed Studies on the Synthesis of Derivatives of Marine-Derived Bostrycin and Their Structure-Activity Relationship against Tumor Cells
title_short Studies on the Synthesis of Derivatives of Marine-Derived Bostrycin and Their Structure-Activity Relationship against Tumor Cells
title_sort studies on the synthesis of derivatives of marine-derived bostrycin and their structure-activity relationship against tumor cells
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3366684/
https://www.ncbi.nlm.nih.gov/pubmed/22690152
http://dx.doi.org/10.3390/md10040932
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