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Tumors with Nonfunctional Retinoblastoma Protein Are Killed by Reduced γ-Tubulin Levels

In various tumors inactivation of growth control is achieved by interfering with the RB1 signaling pathway. Here, we describe that RB1 and γ-tubulin proteins moderate each other's expression by binding to their respective gene promoters. Simultaneous reduction of RB1 and γ-tubulin protein level...

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Detalles Bibliográficos
Autores principales:	Ehlén, Åsa, Rosselló, Catalina A., von Stedingk, Kristoffer, Höög, Greta, Nilsson, Elise, Pettersson, Helen M., Jirström, Karin, Alvarado-Kristensson, Maria
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2012
Materias:	Molecular Bases of Disease
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3366773/ https://www.ncbi.nlm.nih.gov/pubmed/22493456 http://dx.doi.org/10.1074/jbc.M112.357038

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