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Highly sensitive magnetite nano clusters for MR cell imaging
High sensitivity and suitable sizes are essential for magnetic iron oxide contrast agents for cell imaging. In this study, we have fabricated highly MR sensitive magnetite nanoclusters (MNCs) with tunable sizes. These clusters demonstrate high MR sensitivity. Especially, water suspensions of the MNC...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3366891/ https://www.ncbi.nlm.nih.gov/pubmed/22462693 http://dx.doi.org/10.1186/1556-276X-7-204 |
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author | Li, Mingli Gu, Hongchen Zhang, Chunfu |
author_facet | Li, Mingli Gu, Hongchen Zhang, Chunfu |
author_sort | Li, Mingli |
collection | PubMed |
description | High sensitivity and suitable sizes are essential for magnetic iron oxide contrast agents for cell imaging. In this study, we have fabricated highly MR sensitive magnetite nanoclusters (MNCs) with tunable sizes. These clusters demonstrate high MR sensitivity. Especially, water suspensions of the MNCs with average size of 63 nm have transverse relaxivity as high as 630 s(-1)mM(-1), which is among the most sensitive iron oxide contrast agents ever reported. Importantly, such MNCs have no adverse effects on cells (RAW 264.7). When used for cell imaging, they demonstrate much higher efficiency and sensitivity than those of SHU555A (Resovist), a commercially available contrast agent, both in vitro and in vivo, with detection limits of 3,000 and 10,000 labeled cells, respectively. The studied MNCs are sensitive for cell imaging and promising for MR cell tracking in clinics. |
format | Online Article Text |
id | pubmed-3366891 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Springer |
record_format | MEDLINE/PubMed |
spelling | pubmed-33668912012-06-05 Highly sensitive magnetite nano clusters for MR cell imaging Li, Mingli Gu, Hongchen Zhang, Chunfu Nanoscale Res Lett Nano Express High sensitivity and suitable sizes are essential for magnetic iron oxide contrast agents for cell imaging. In this study, we have fabricated highly MR sensitive magnetite nanoclusters (MNCs) with tunable sizes. These clusters demonstrate high MR sensitivity. Especially, water suspensions of the MNCs with average size of 63 nm have transverse relaxivity as high as 630 s(-1)mM(-1), which is among the most sensitive iron oxide contrast agents ever reported. Importantly, such MNCs have no adverse effects on cells (RAW 264.7). When used for cell imaging, they demonstrate much higher efficiency and sensitivity than those of SHU555A (Resovist), a commercially available contrast agent, both in vitro and in vivo, with detection limits of 3,000 and 10,000 labeled cells, respectively. The studied MNCs are sensitive for cell imaging and promising for MR cell tracking in clinics. Springer 2012-03-31 /pmc/articles/PMC3366891/ /pubmed/22462693 http://dx.doi.org/10.1186/1556-276X-7-204 Text en Copyright ©2012 Li et al; licensee Springer. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Nano Express Li, Mingli Gu, Hongchen Zhang, Chunfu Highly sensitive magnetite nano clusters for MR cell imaging |
title | Highly sensitive magnetite nano clusters for MR cell imaging |
title_full | Highly sensitive magnetite nano clusters for MR cell imaging |
title_fullStr | Highly sensitive magnetite nano clusters for MR cell imaging |
title_full_unstemmed | Highly sensitive magnetite nano clusters for MR cell imaging |
title_short | Highly sensitive magnetite nano clusters for MR cell imaging |
title_sort | highly sensitive magnetite nano clusters for mr cell imaging |
topic | Nano Express |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3366891/ https://www.ncbi.nlm.nih.gov/pubmed/22462693 http://dx.doi.org/10.1186/1556-276X-7-204 |
work_keys_str_mv | AT limingli highlysensitivemagnetitenanoclustersformrcellimaging AT guhongchen highlysensitivemagnetitenanoclustersformrcellimaging AT zhangchunfu highlysensitivemagnetitenanoclustersformrcellimaging |