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Regulation of reverse cholesterol transport - a comprehensive appraisal of available animal studies
Plasma levels of high density lipoprotein (HDL) cholesterol are strongly inversely correlated to the risk of atherosclerotic cardiovascular disease. A major recognized functional property of HDL particles is to elicit cholesterol efflux and consequently mediate reverse cholesterol transport (RCT). T...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3366910/ https://www.ncbi.nlm.nih.gov/pubmed/22458435 http://dx.doi.org/10.1186/1743-7075-9-25 |
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author | Annema, Wijtske Tietge, Uwe JF |
author_facet | Annema, Wijtske Tietge, Uwe JF |
author_sort | Annema, Wijtske |
collection | PubMed |
description | Plasma levels of high density lipoprotein (HDL) cholesterol are strongly inversely correlated to the risk of atherosclerotic cardiovascular disease. A major recognized functional property of HDL particles is to elicit cholesterol efflux and consequently mediate reverse cholesterol transport (RCT). The recent introduction of a surrogate method aiming at determining specifically RCT from the macrophage compartment has facilitated research on the different components and pathways relevant for RCT. The current review provides a comprehensive overview of studies carried out on macrophage-specific RCT including a quick reference guide of available data. Knowledge and insights gained on the regulation of the RCT pathway are summarized. A discussion of methodological issues as well as of the respective relevance of specific pathways for RCT is also included. |
format | Online Article Text |
id | pubmed-3366910 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-33669102012-06-05 Regulation of reverse cholesterol transport - a comprehensive appraisal of available animal studies Annema, Wijtske Tietge, Uwe JF Nutr Metab (Lond) Review Plasma levels of high density lipoprotein (HDL) cholesterol are strongly inversely correlated to the risk of atherosclerotic cardiovascular disease. A major recognized functional property of HDL particles is to elicit cholesterol efflux and consequently mediate reverse cholesterol transport (RCT). The recent introduction of a surrogate method aiming at determining specifically RCT from the macrophage compartment has facilitated research on the different components and pathways relevant for RCT. The current review provides a comprehensive overview of studies carried out on macrophage-specific RCT including a quick reference guide of available data. Knowledge and insights gained on the regulation of the RCT pathway are summarized. A discussion of methodological issues as well as of the respective relevance of specific pathways for RCT is also included. BioMed Central 2012-03-29 /pmc/articles/PMC3366910/ /pubmed/22458435 http://dx.doi.org/10.1186/1743-7075-9-25 Text en Copyright ©2012 Annema and Tietge; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Annema, Wijtske Tietge, Uwe JF Regulation of reverse cholesterol transport - a comprehensive appraisal of available animal studies |
title | Regulation of reverse cholesterol transport - a comprehensive appraisal of available animal studies |
title_full | Regulation of reverse cholesterol transport - a comprehensive appraisal of available animal studies |
title_fullStr | Regulation of reverse cholesterol transport - a comprehensive appraisal of available animal studies |
title_full_unstemmed | Regulation of reverse cholesterol transport - a comprehensive appraisal of available animal studies |
title_short | Regulation of reverse cholesterol transport - a comprehensive appraisal of available animal studies |
title_sort | regulation of reverse cholesterol transport - a comprehensive appraisal of available animal studies |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3366910/ https://www.ncbi.nlm.nih.gov/pubmed/22458435 http://dx.doi.org/10.1186/1743-7075-9-25 |
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