Cargando…

Regulation of reverse cholesterol transport - a comprehensive appraisal of available animal studies

Plasma levels of high density lipoprotein (HDL) cholesterol are strongly inversely correlated to the risk of atherosclerotic cardiovascular disease. A major recognized functional property of HDL particles is to elicit cholesterol efflux and consequently mediate reverse cholesterol transport (RCT). T...

Descripción completa

Detalles Bibliográficos
Autores principales: Annema, Wijtske, Tietge, Uwe JF
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3366910/
https://www.ncbi.nlm.nih.gov/pubmed/22458435
http://dx.doi.org/10.1186/1743-7075-9-25
_version_ 1782234785324728320
author Annema, Wijtske
Tietge, Uwe JF
author_facet Annema, Wijtske
Tietge, Uwe JF
author_sort Annema, Wijtske
collection PubMed
description Plasma levels of high density lipoprotein (HDL) cholesterol are strongly inversely correlated to the risk of atherosclerotic cardiovascular disease. A major recognized functional property of HDL particles is to elicit cholesterol efflux and consequently mediate reverse cholesterol transport (RCT). The recent introduction of a surrogate method aiming at determining specifically RCT from the macrophage compartment has facilitated research on the different components and pathways relevant for RCT. The current review provides a comprehensive overview of studies carried out on macrophage-specific RCT including a quick reference guide of available data. Knowledge and insights gained on the regulation of the RCT pathway are summarized. A discussion of methodological issues as well as of the respective relevance of specific pathways for RCT is also included.
format Online
Article
Text
id pubmed-3366910
institution National Center for Biotechnology Information
language English
publishDate 2012
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-33669102012-06-05 Regulation of reverse cholesterol transport - a comprehensive appraisal of available animal studies Annema, Wijtske Tietge, Uwe JF Nutr Metab (Lond) Review Plasma levels of high density lipoprotein (HDL) cholesterol are strongly inversely correlated to the risk of atherosclerotic cardiovascular disease. A major recognized functional property of HDL particles is to elicit cholesterol efflux and consequently mediate reverse cholesterol transport (RCT). The recent introduction of a surrogate method aiming at determining specifically RCT from the macrophage compartment has facilitated research on the different components and pathways relevant for RCT. The current review provides a comprehensive overview of studies carried out on macrophage-specific RCT including a quick reference guide of available data. Knowledge and insights gained on the regulation of the RCT pathway are summarized. A discussion of methodological issues as well as of the respective relevance of specific pathways for RCT is also included. BioMed Central 2012-03-29 /pmc/articles/PMC3366910/ /pubmed/22458435 http://dx.doi.org/10.1186/1743-7075-9-25 Text en Copyright ©2012 Annema and Tietge; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Annema, Wijtske
Tietge, Uwe JF
Regulation of reverse cholesterol transport - a comprehensive appraisal of available animal studies
title Regulation of reverse cholesterol transport - a comprehensive appraisal of available animal studies
title_full Regulation of reverse cholesterol transport - a comprehensive appraisal of available animal studies
title_fullStr Regulation of reverse cholesterol transport - a comprehensive appraisal of available animal studies
title_full_unstemmed Regulation of reverse cholesterol transport - a comprehensive appraisal of available animal studies
title_short Regulation of reverse cholesterol transport - a comprehensive appraisal of available animal studies
title_sort regulation of reverse cholesterol transport - a comprehensive appraisal of available animal studies
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3366910/
https://www.ncbi.nlm.nih.gov/pubmed/22458435
http://dx.doi.org/10.1186/1743-7075-9-25
work_keys_str_mv AT annemawijtske regulationofreversecholesteroltransportacomprehensiveappraisalofavailableanimalstudies
AT tietgeuwejf regulationofreversecholesteroltransportacomprehensiveappraisalofavailableanimalstudies