E3-14.7K Is Recruited to TNF-Receptor 1 and Blocks TNF Cytolysis Independent from Interaction with Optineurin

Escape from the host immune system is essential for intracellular pathogens. The adenoviral protein E3-14.7K (14.7K) is known as a general inhibitor of tumor necrosis factor (TNF)-induced apoptosis. It efficiently blocks TNF-receptor 1 (TNFR1) internalization but the underlying molecular mechanism s...

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Detalles Bibliográficos
Autores principales: Klingseisen, Laura, Ehrenschwender, Martin, Heigl, Ulrike, Wajant, Harald, Hehlgans, Thomas, Schütze, Stefan, Schneider-Brachert, Wulf
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3366936/
https://www.ncbi.nlm.nih.gov/pubmed/22675546
http://dx.doi.org/10.1371/journal.pone.0038348

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