In Vivo Human Apolipoprotein E Isoform Fractional Turnover Rates in the CNS

Apolipoprotein E (ApoE) is the strongest genetic risk factor for Alzheimer’s disease and has been implicated in the risk for other neurological disorders. The three common ApoE isoforms (ApoE2, E3, and E4) each differ by a single amino acid, with ApoE4 increasing and ApoE2 decreasing the risk of Alz...

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Detalles Bibliográficos
Autores principales: Wildsmith, Kristin R., Basak, Jacob M., Patterson, Bruce W., Pyatkivskyy, Yuriy, Kim, Jungsu, Yarasheski, Kevin E., Wang, Jennifer X., Mawuenyega, Kwasi G., Jiang, Hong, Parsadanian, Maia, Yoon, Hyejin, Kasten, Tom, Sigurdson, Wendy C., Xiong, Chengjie, Goate, Alison, Holtzman, David M., Bateman, Randall J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3366983/
https://www.ncbi.nlm.nih.gov/pubmed/22675504
http://dx.doi.org/10.1371/journal.pone.0038013

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