Parenteral Pethidine for labour pain relief and substance use disorder: 20-year follow-up cohort study in offspring

OBJECTIVE: To determine whether use of intrapartum Pethidine pain analgesia increases the risk for substance use disorder in adult offspring. DESIGN: Analysis of data from a cohort study. SETTING: Academic hospital in Leiden, the Netherlands. PARTICIPANTS: 133 cases and 164 control individuals, aged...

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Detalles Bibliográficos
Autores principales: Pereira, Robert Rodrigues, Kanhai, Humphrey, Rosendaal, Frits, van Dommelen, Paula, Swaab, Dick, Rodrigues Pereira, Erik, van de Wetering, Ben
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Group 2012
Materias:
Anaesthesia
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3367141/
https://www.ncbi.nlm.nih.gov/pubmed/22649173
http://dx.doi.org/10.1136/bmjopen-2011-000719
Descripción
Sumario:OBJECTIVE: To determine whether use of intrapartum Pethidine pain analgesia increases the risk for substance use disorder in adult offspring. DESIGN: Analysis of data from a cohort study. SETTING: Academic hospital in Leiden, the Netherlands. PARTICIPANTS: 133 cases and 164 control individuals, aged 18–20 years at follow-up. MAIN OUTCOME MEASURE: Incidence of substance use disorder or use of alcohol and tobacco. RESULTS: The lifetime use of addictive substances in children exposed to intrapartum Pethidine analgesia was 45% of 133 children versus 48% of 164 not-exposed subjects (adjusted OR=0.79, 95% CI 0.48 to 1.29). Recent use of alcohol, tobacco and hard drugs showed no statistical difference either. CONCLUSION: Pethidine for labour pain medication appears not to be associated with substance misuse or smoking in later life.

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