Parenteral Pethidine for labour pain relief and substance use disorder: 20-year follow-up cohort study in offspring

OBJECTIVE: To determine whether use of intrapartum Pethidine pain analgesia increases the risk for substance use disorder in adult offspring. DESIGN: Analysis of data from a cohort study. SETTING: Academic hospital in Leiden, the Netherlands. PARTICIPANTS: 133 cases and 164 control individuals, aged...

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Autores principales: Pereira, Robert Rodrigues, Kanhai, Humphrey, Rosendaal, Frits, van Dommelen, Paula, Swaab, Dick, Rodrigues Pereira, Erik, van de Wetering, Ben
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Group 2012
Materias:
Anaesthesia
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3367141/
https://www.ncbi.nlm.nih.gov/pubmed/22649173
http://dx.doi.org/10.1136/bmjopen-2011-000719
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author Pereira, Robert Rodrigues
Kanhai, Humphrey
Rosendaal, Frits
van Dommelen, Paula
Swaab, Dick
Rodrigues Pereira, Erik
van de Wetering, Ben
author_facet Pereira, Robert Rodrigues
Kanhai, Humphrey
Rosendaal, Frits
van Dommelen, Paula
Swaab, Dick
Rodrigues Pereira, Erik
van de Wetering, Ben
author_sort Pereira, Robert Rodrigues
collection PubMed
description OBJECTIVE: To determine whether use of intrapartum Pethidine pain analgesia increases the risk for substance use disorder in adult offspring. DESIGN: Analysis of data from a cohort study. SETTING: Academic hospital in Leiden, the Netherlands. PARTICIPANTS: 133 cases and 164 control individuals, aged 18–20 years at follow-up. MAIN OUTCOME MEASURE: Incidence of substance use disorder or use of alcohol and tobacco. RESULTS: The lifetime use of addictive substances in children exposed to intrapartum Pethidine analgesia was 45% of 133 children versus 48% of 164 not-exposed subjects (adjusted OR=0.79, 95% CI 0.48 to 1.29). Recent use of alcohol, tobacco and hard drugs showed no statistical difference either. CONCLUSION: Pethidine for labour pain medication appears not to be associated with substance misuse or smoking in later life.
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spelling pubmed-33671412012-06-07 Parenteral Pethidine for labour pain relief and substance use disorder: 20-year follow-up cohort study in offspring Pereira, Robert Rodrigues Kanhai, Humphrey Rosendaal, Frits van Dommelen, Paula Swaab, Dick Rodrigues Pereira, Erik van de Wetering, Ben BMJ Open Anaesthesia OBJECTIVE: To determine whether use of intrapartum Pethidine pain analgesia increases the risk for substance use disorder in adult offspring. DESIGN: Analysis of data from a cohort study. SETTING: Academic hospital in Leiden, the Netherlands. PARTICIPANTS: 133 cases and 164 control individuals, aged 18–20 years at follow-up. MAIN OUTCOME MEASURE: Incidence of substance use disorder or use of alcohol and tobacco. RESULTS: The lifetime use of addictive substances in children exposed to intrapartum Pethidine analgesia was 45% of 133 children versus 48% of 164 not-exposed subjects (adjusted OR=0.79, 95% CI 0.48 to 1.29). Recent use of alcohol, tobacco and hard drugs showed no statistical difference either. CONCLUSION: Pethidine for labour pain medication appears not to be associated with substance misuse or smoking in later life. BMJ Group 2012-05-30 /pmc/articles/PMC3367141/ /pubmed/22649173 http://dx.doi.org/10.1136/bmjopen-2011-000719 Text en © 2012, Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions. This is an open-access article distributed under the terms of the Creative Commons Attribution Non-commercial License, which permits use, distribution, and reproduction in any medium, provided the original work is properly cited, the use is non commercial and is otherwise in compliance with the license. See: http://creativecommons.org/licenses/by-nc/2.0/ and http://creativecommons.org/licenses/by-nc/2.0/legalcode.
spellingShingle Anaesthesia
Pereira, Robert Rodrigues
Kanhai, Humphrey
Rosendaal, Frits
van Dommelen, Paula
Swaab, Dick
Rodrigues Pereira, Erik
van de Wetering, Ben
Parenteral Pethidine for labour pain relief and substance use disorder: 20-year follow-up cohort study in offspring
title Parenteral Pethidine for labour pain relief and substance use disorder: 20-year follow-up cohort study in offspring
title_full Parenteral Pethidine for labour pain relief and substance use disorder: 20-year follow-up cohort study in offspring
title_fullStr Parenteral Pethidine for labour pain relief and substance use disorder: 20-year follow-up cohort study in offspring
title_full_unstemmed Parenteral Pethidine for labour pain relief and substance use disorder: 20-year follow-up cohort study in offspring
title_short Parenteral Pethidine for labour pain relief and substance use disorder: 20-year follow-up cohort study in offspring
title_sort parenteral pethidine for labour pain relief and substance use disorder: 20-year follow-up cohort study in offspring
topic Anaesthesia
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3367141/
https://www.ncbi.nlm.nih.gov/pubmed/22649173
http://dx.doi.org/10.1136/bmjopen-2011-000719
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