Lactate, a product of glycolytic metabolism, inhibits histone deacetylase activity and promotes changes in gene expression

Chemical inhibitors of histone deacetylase (HDAC) activity are used as experimental tools to induce histone hyperacetylation and deregulate gene transcription, but it is not known whether the inhibition of HDACs plays any part in the normal physiological regulation of transcription. Using both in vi...

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Detalles Bibliográficos
Autores principales: Latham, Tom, Mackay, Logan, Sproul, Duncan, Karim, Muhammed, Culley, Jayne, Harrison, David J, Hayward, Larry, Langridge-Smith, Pat, Gilbert, Nick, Ramsahoye, Bernard H
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2012
Materias:
Gene Regulation, Chromatin and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3367171/
https://www.ncbi.nlm.nih.gov/pubmed/22323521
http://dx.doi.org/10.1093/nar/gks066

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