HuR protein attenuates miRNA-mediated repression by promoting miRISC dissociation from the target RNA

The microRNA (miRNA)-mediated repression of protein synthesis in mammalian cells is a reversible process. Target mRNAs with regulatory AU-rich elements (AREs) in their 3′-untranslated regions (3′-UTR) can be relieved of miRNA repression under cellular stress in a process involving the embryonic leth...

Descripción completa

Detalles Bibliográficos
Autores principales: Kundu, Pradipta, Fabian, Marc R., Sonenberg, Nahum, Bhattacharyya, Suvendra N., Filipowicz, Witold
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2012
Materias:
RNA
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3367187/
https://www.ncbi.nlm.nih.gov/pubmed/22362743
http://dx.doi.org/10.1093/nar/gks148

Ejemplares similares

Ejemplares similares