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Post-transcriptional homeostasis and regulation of MCM2–7 in mammalian cells

The MiniChromosome Maintenance 2-7 (MCM2-7) complex provides essential replicative helicase function. Insufficient MCMs impair the cell cycle and cause genomic instability (GIN), leading to cancer and developmental defects in mice. Remarkably, depletion or mutation of one Mcm can decrease all Mcm le...

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Detalles Bibliográficos
Autores principales:	Chuang, Chen-Hua, Yang, Dian, Bai, Gongshi, Freeland, Amy, Pruitt, Steven C., Schimenti, John C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2012
Materias:	Genome Integrity, Repair and Replication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3367205/ https://www.ncbi.nlm.nih.gov/pubmed/22362746 http://dx.doi.org/10.1093/nar/gks176

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