Cargando…
Biomarker Genes for Detecting Estrogenic Activity of Endocrine Disruptors via Estrogen Receptors
Endocrine disruptors (EDs) are compounds used in various industrial products, drugs, and cosmetics. They can be found in the environment and disturb the endocrine and reproductive systems, resulting in adverse effects to humans and wildlife such as birth defects and developmental disorders. Since se...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2012
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3367271/ https://www.ncbi.nlm.nih.gov/pubmed/22690157 http://dx.doi.org/10.3390/ijerph9030698 |
_version_ | 1782234825623601152 |
---|---|
author | Jung, Eui-Man An, Beum-Soo Yang, Hyun Choi, Kyung-Chul Jeung, Eui-Bae |
author_facet | Jung, Eui-Man An, Beum-Soo Yang, Hyun Choi, Kyung-Chul Jeung, Eui-Bae |
author_sort | Jung, Eui-Man |
collection | PubMed |
description | Endocrine disruptors (EDs) are compounds used in various industrial products, drugs, and cosmetics. They can be found in the environment and disturb the endocrine and reproductive systems, resulting in adverse effects to humans and wildlife such as birth defects and developmental disorders. Since several EDs have a structure similar to that of endogenous steroid hormones such as estrogens, they intend to have an affinity for steroid hormone receptors and alter hormone-mediated metabolism by binding to these receptors. EDs are therefore a global concern and assays should be developed to efficiently determine whether these compounds are detrimental to biological systems. Diverse experimental methods may help determine the endocrine disrupting potential of EDs and evaluate the adverse effects of a single and/or combination of these reagents. Currently, biomarkers have been employed to objectively measure EDs potency and understand the underlying mechanisms. Further studies are required to develop ideal screening methods and biomarkers to determine EDs potency at environmentally relevant concentrations. In this review, we describe the biomarkers for estrogenicity of EDs identified both in vitro and in vivo, and introduce a biomarker, cabindin-D(9k) (CaBP-9k), that may be used to assess estrogenic activity of EDs. |
format | Online Article Text |
id | pubmed-3367271 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-33672712012-06-11 Biomarker Genes for Detecting Estrogenic Activity of Endocrine Disruptors via Estrogen Receptors Jung, Eui-Man An, Beum-Soo Yang, Hyun Choi, Kyung-Chul Jeung, Eui-Bae Int J Environ Res Public Health Review Endocrine disruptors (EDs) are compounds used in various industrial products, drugs, and cosmetics. They can be found in the environment and disturb the endocrine and reproductive systems, resulting in adverse effects to humans and wildlife such as birth defects and developmental disorders. Since several EDs have a structure similar to that of endogenous steroid hormones such as estrogens, they intend to have an affinity for steroid hormone receptors and alter hormone-mediated metabolism by binding to these receptors. EDs are therefore a global concern and assays should be developed to efficiently determine whether these compounds are detrimental to biological systems. Diverse experimental methods may help determine the endocrine disrupting potential of EDs and evaluate the adverse effects of a single and/or combination of these reagents. Currently, biomarkers have been employed to objectively measure EDs potency and understand the underlying mechanisms. Further studies are required to develop ideal screening methods and biomarkers to determine EDs potency at environmentally relevant concentrations. In this review, we describe the biomarkers for estrogenicity of EDs identified both in vitro and in vivo, and introduce a biomarker, cabindin-D(9k) (CaBP-9k), that may be used to assess estrogenic activity of EDs. MDPI 2012-02-24 2012-03 /pmc/articles/PMC3367271/ /pubmed/22690157 http://dx.doi.org/10.3390/ijerph9030698 Text en © 2012 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). |
spellingShingle | Review Jung, Eui-Man An, Beum-Soo Yang, Hyun Choi, Kyung-Chul Jeung, Eui-Bae Biomarker Genes for Detecting Estrogenic Activity of Endocrine Disruptors via Estrogen Receptors |
title | Biomarker Genes for Detecting Estrogenic Activity of Endocrine Disruptors via Estrogen Receptors |
title_full | Biomarker Genes for Detecting Estrogenic Activity of Endocrine Disruptors via Estrogen Receptors |
title_fullStr | Biomarker Genes for Detecting Estrogenic Activity of Endocrine Disruptors via Estrogen Receptors |
title_full_unstemmed | Biomarker Genes for Detecting Estrogenic Activity of Endocrine Disruptors via Estrogen Receptors |
title_short | Biomarker Genes for Detecting Estrogenic Activity of Endocrine Disruptors via Estrogen Receptors |
title_sort | biomarker genes for detecting estrogenic activity of endocrine disruptors via estrogen receptors |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3367271/ https://www.ncbi.nlm.nih.gov/pubmed/22690157 http://dx.doi.org/10.3390/ijerph9030698 |
work_keys_str_mv | AT jungeuiman biomarkergenesfordetectingestrogenicactivityofendocrinedisruptorsviaestrogenreceptors AT anbeumsoo biomarkergenesfordetectingestrogenicactivityofendocrinedisruptorsviaestrogenreceptors AT yanghyun biomarkergenesfordetectingestrogenicactivityofendocrinedisruptorsviaestrogenreceptors AT choikyungchul biomarkergenesfordetectingestrogenicactivityofendocrinedisruptorsviaestrogenreceptors AT jeungeuibae biomarkergenesfordetectingestrogenicactivityofendocrinedisruptorsviaestrogenreceptors |