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Biomarker Genes for Detecting Estrogenic Activity of Endocrine Disruptors via Estrogen Receptors

Endocrine disruptors (EDs) are compounds used in various industrial products, drugs, and cosmetics. They can be found in the environment and disturb the endocrine and reproductive systems, resulting in adverse effects to humans and wildlife such as birth defects and developmental disorders. Since se...

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Autores principales: Jung, Eui-Man, An, Beum-Soo, Yang, Hyun, Choi, Kyung-Chul, Jeung, Eui-Bae
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3367271/
https://www.ncbi.nlm.nih.gov/pubmed/22690157
http://dx.doi.org/10.3390/ijerph9030698
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author Jung, Eui-Man
An, Beum-Soo
Yang, Hyun
Choi, Kyung-Chul
Jeung, Eui-Bae
author_facet Jung, Eui-Man
An, Beum-Soo
Yang, Hyun
Choi, Kyung-Chul
Jeung, Eui-Bae
author_sort Jung, Eui-Man
collection PubMed
description Endocrine disruptors (EDs) are compounds used in various industrial products, drugs, and cosmetics. They can be found in the environment and disturb the endocrine and reproductive systems, resulting in adverse effects to humans and wildlife such as birth defects and developmental disorders. Since several EDs have a structure similar to that of endogenous steroid hormones such as estrogens, they intend to have an affinity for steroid hormone receptors and alter hormone-mediated metabolism by binding to these receptors. EDs are therefore a global concern and assays should be developed to efficiently determine whether these compounds are detrimental to biological systems. Diverse experimental methods may help determine the endocrine disrupting potential of EDs and evaluate the adverse effects of a single and/or combination of these reagents. Currently, biomarkers have been employed to objectively measure EDs potency and understand the underlying mechanisms. Further studies are required to develop ideal screening methods and biomarkers to determine EDs potency at environmentally relevant concentrations. In this review, we describe the biomarkers for estrogenicity of EDs identified both in vitro and in vivo, and introduce a biomarker, cabindin-D(9k) (CaBP-9k), that may be used to assess estrogenic activity of EDs.
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spelling pubmed-33672712012-06-11 Biomarker Genes for Detecting Estrogenic Activity of Endocrine Disruptors via Estrogen Receptors Jung, Eui-Man An, Beum-Soo Yang, Hyun Choi, Kyung-Chul Jeung, Eui-Bae Int J Environ Res Public Health Review Endocrine disruptors (EDs) are compounds used in various industrial products, drugs, and cosmetics. They can be found in the environment and disturb the endocrine and reproductive systems, resulting in adverse effects to humans and wildlife such as birth defects and developmental disorders. Since several EDs have a structure similar to that of endogenous steroid hormones such as estrogens, they intend to have an affinity for steroid hormone receptors and alter hormone-mediated metabolism by binding to these receptors. EDs are therefore a global concern and assays should be developed to efficiently determine whether these compounds are detrimental to biological systems. Diverse experimental methods may help determine the endocrine disrupting potential of EDs and evaluate the adverse effects of a single and/or combination of these reagents. Currently, biomarkers have been employed to objectively measure EDs potency and understand the underlying mechanisms. Further studies are required to develop ideal screening methods and biomarkers to determine EDs potency at environmentally relevant concentrations. In this review, we describe the biomarkers for estrogenicity of EDs identified both in vitro and in vivo, and introduce a biomarker, cabindin-D(9k) (CaBP-9k), that may be used to assess estrogenic activity of EDs. MDPI 2012-02-24 2012-03 /pmc/articles/PMC3367271/ /pubmed/22690157 http://dx.doi.org/10.3390/ijerph9030698 Text en © 2012 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Review
Jung, Eui-Man
An, Beum-Soo
Yang, Hyun
Choi, Kyung-Chul
Jeung, Eui-Bae
Biomarker Genes for Detecting Estrogenic Activity of Endocrine Disruptors via Estrogen Receptors
title Biomarker Genes for Detecting Estrogenic Activity of Endocrine Disruptors via Estrogen Receptors
title_full Biomarker Genes for Detecting Estrogenic Activity of Endocrine Disruptors via Estrogen Receptors
title_fullStr Biomarker Genes for Detecting Estrogenic Activity of Endocrine Disruptors via Estrogen Receptors
title_full_unstemmed Biomarker Genes for Detecting Estrogenic Activity of Endocrine Disruptors via Estrogen Receptors
title_short Biomarker Genes for Detecting Estrogenic Activity of Endocrine Disruptors via Estrogen Receptors
title_sort biomarker genes for detecting estrogenic activity of endocrine disruptors via estrogen receptors
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3367271/
https://www.ncbi.nlm.nih.gov/pubmed/22690157
http://dx.doi.org/10.3390/ijerph9030698
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