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Effect of Age on Clinical Presentation and Outcome of Patients Hospitalized with Acute Coronary Syndrome: A 20-Year Registry in a Middle Eastern Country

INTRODUCTION: Despite the fact that the elderly constitute an increasingly important group of patients with acute coronary syndrome (ACS), they are often excluded from clinical trials and are underrepresented in clinical registries. AIMS: To evaluate the impact of age in patients hospitalized with A...

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Autores principales: Ahmed, Emad, El-Menyar, Ayman, Singh, Rajvir, Al Binali1, Hajar A, Al Suwaidi, Jassim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Bentham Open 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3367301/
https://www.ncbi.nlm.nih.gov/pubmed/22670161
http://dx.doi.org/10.2174/1874192401206010060
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author Ahmed, Emad
El-Menyar, Ayman
Singh, Rajvir
Al Binali1, Hajar A
Al Suwaidi, Jassim
author_facet Ahmed, Emad
El-Menyar, Ayman
Singh, Rajvir
Al Binali1, Hajar A
Al Suwaidi, Jassim
author_sort Ahmed, Emad
collection PubMed
description INTRODUCTION: Despite the fact that the elderly constitute an increasingly important group of patients with acute coronary syndrome (ACS), they are often excluded from clinical trials and are underrepresented in clinical registries. AIMS: To evaluate the impact of age in patients hospitalized with ACS. METHODS: Data collected for all patients presenting with ACS (n=16,744) who were admitted in Qatar during the period (1991-2010) and were analyzed according to age into 3 groups (≤50 years [41.4%], 51-70 years [48.7%] and >70 years [9.8%]). RESULTS: Older patients were more likely to be women and have hypertension, diabetes mellitus, and renal failure, while younger patients were more likely to be smokers. Non-ST-elevation myocardial infarction and heart failure were more prevalent in older patients. Older age was associated with undertreatment with evidence-based therapies and had higher mortality rate. Age was independent predictor for mortality. Over the study period, the relative reduction in mortality rates was higher in the younger compared with the older patients (61, 45.9 and 35.5%). CONCLUSIONS: Despite being a higher-risk group, older patients were undertreated with evidence based therapy and had worse short-term outcome. Guidelines adherence and improvement in hospital care for elderly patients with ACS may potentially reduce morbidity and mortality.
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spelling pubmed-33673012012-06-05 Effect of Age on Clinical Presentation and Outcome of Patients Hospitalized with Acute Coronary Syndrome: A 20-Year Registry in a Middle Eastern Country Ahmed, Emad El-Menyar, Ayman Singh, Rajvir Al Binali1, Hajar A Al Suwaidi, Jassim Open Cardiovasc Med J Article INTRODUCTION: Despite the fact that the elderly constitute an increasingly important group of patients with acute coronary syndrome (ACS), they are often excluded from clinical trials and are underrepresented in clinical registries. AIMS: To evaluate the impact of age in patients hospitalized with ACS. METHODS: Data collected for all patients presenting with ACS (n=16,744) who were admitted in Qatar during the period (1991-2010) and were analyzed according to age into 3 groups (≤50 years [41.4%], 51-70 years [48.7%] and >70 years [9.8%]). RESULTS: Older patients were more likely to be women and have hypertension, diabetes mellitus, and renal failure, while younger patients were more likely to be smokers. Non-ST-elevation myocardial infarction and heart failure were more prevalent in older patients. Older age was associated with undertreatment with evidence-based therapies and had higher mortality rate. Age was independent predictor for mortality. Over the study period, the relative reduction in mortality rates was higher in the younger compared with the older patients (61, 45.9 and 35.5%). CONCLUSIONS: Despite being a higher-risk group, older patients were undertreated with evidence based therapy and had worse short-term outcome. Guidelines adherence and improvement in hospital care for elderly patients with ACS may potentially reduce morbidity and mortality. Bentham Open 2012-05-18 /pmc/articles/PMC3367301/ /pubmed/22670161 http://dx.doi.org/10.2174/1874192401206010060 Text en © Ahmed et al.; Licensee Bentham Open. http://creativecommons.org/licenses/by-nc/3.0/ This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
spellingShingle Article
Ahmed, Emad
El-Menyar, Ayman
Singh, Rajvir
Al Binali1, Hajar A
Al Suwaidi, Jassim
Effect of Age on Clinical Presentation and Outcome of Patients Hospitalized with Acute Coronary Syndrome: A 20-Year Registry in a Middle Eastern Country
title Effect of Age on Clinical Presentation and Outcome of Patients Hospitalized with Acute Coronary Syndrome: A 20-Year Registry in a Middle Eastern Country
title_full Effect of Age on Clinical Presentation and Outcome of Patients Hospitalized with Acute Coronary Syndrome: A 20-Year Registry in a Middle Eastern Country
title_fullStr Effect of Age on Clinical Presentation and Outcome of Patients Hospitalized with Acute Coronary Syndrome: A 20-Year Registry in a Middle Eastern Country
title_full_unstemmed Effect of Age on Clinical Presentation and Outcome of Patients Hospitalized with Acute Coronary Syndrome: A 20-Year Registry in a Middle Eastern Country
title_short Effect of Age on Clinical Presentation and Outcome of Patients Hospitalized with Acute Coronary Syndrome: A 20-Year Registry in a Middle Eastern Country
title_sort effect of age on clinical presentation and outcome of patients hospitalized with acute coronary syndrome: a 20-year registry in a middle eastern country
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3367301/
https://www.ncbi.nlm.nih.gov/pubmed/22670161
http://dx.doi.org/10.2174/1874192401206010060
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