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Analytic Markovian Rates for Generalized Protein Structure Evolution

A general understanding of the complex phenomenon of protein evolution requires the accurate description of the constraints that define the sub-space of proteins with mutations that do not appreciably reduce the fitness of the organism. Such constraints can have multiple origins, in this work we pre...

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Detalles Bibliográficos
Autores principales: Coluzza, Ivan, MacDonald, James T., Sadowski, Michael I., Taylor, William R., Goldstein, Richard A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3367531/
https://www.ncbi.nlm.nih.gov/pubmed/22693543
http://dx.doi.org/10.1371/journal.pone.0034228