Cargando…

Trypanosomiasis Relapse after Melarsoprol Therapy, Democratic Republic of Congo, 1982–2001

Recently, a high proportion of patients with late-stage Trypanosoma brucei gambiense trypanosomiasis, who had been treated with melarsoprol in some disease-endemic areas, subsequently relapsed. To determine whether the frequency of postmelarsoprol relapses increased over time, we reviewed data from...

Descripción completa

Detalles Bibliográficos
Autores principales: Pépin, Jacques, Mpia, Bokelo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Centers for Disease Control and Prevention 2005
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3367572/
https://www.ncbi.nlm.nih.gov/pubmed/15963288
http://dx.doi.org/10.3201/eid1106.050036
_version_ 1782234856239923200
author Pépin, Jacques
Mpia, Bokelo
author_facet Pépin, Jacques
Mpia, Bokelo
author_sort Pépin, Jacques
collection PubMed
description Recently, a high proportion of patients with late-stage Trypanosoma brucei gambiense trypanosomiasis, who had been treated with melarsoprol in some disease-endemic areas, subsequently relapsed. To determine whether the frequency of postmelarsoprol relapses increased over time, we reviewed data from 2,221 trypanosomiasis patients treated with melarsoprol during this period in Nioki, Democratic Republic of Congo, from 1982 to 2001. The frequency of relapses was 5.6%(31/553), 6.8%(35/512), 4.5%(18/398), 11.4%(34/299), and 5.0%(17/343) for those treated from 1982 to 1985, 1986 to 1989, 1990 to 1993, 1994 to 1997, and 1998 to 2001, respectively. The higher frequency of relapses in 1994 to 1997 was associated with an incremental dosage regimen of melarsoprol. In multivariate analysis, after adjustment for treatment regimen, sex, residence, and trypanosomes in cerebrospinal fluid, postmelarsoprol relapses did not increase in Nioki, perhaps because 1) little drug pressure exists; 2) subtherapeutic doses have rarely been administered; 3) little potential exists for the preferential transmission of melarsoprol-resistant strains.
format Online
Article
Text
id pubmed-3367572
institution National Center for Biotechnology Information
language English
publishDate 2005
publisher Centers for Disease Control and Prevention
record_format MEDLINE/PubMed
spelling pubmed-33675722012-06-07 Trypanosomiasis Relapse after Melarsoprol Therapy, Democratic Republic of Congo, 1982–2001 Pépin, Jacques Mpia, Bokelo Emerg Infect Dis Research Recently, a high proportion of patients with late-stage Trypanosoma brucei gambiense trypanosomiasis, who had been treated with melarsoprol in some disease-endemic areas, subsequently relapsed. To determine whether the frequency of postmelarsoprol relapses increased over time, we reviewed data from 2,221 trypanosomiasis patients treated with melarsoprol during this period in Nioki, Democratic Republic of Congo, from 1982 to 2001. The frequency of relapses was 5.6%(31/553), 6.8%(35/512), 4.5%(18/398), 11.4%(34/299), and 5.0%(17/343) for those treated from 1982 to 1985, 1986 to 1989, 1990 to 1993, 1994 to 1997, and 1998 to 2001, respectively. The higher frequency of relapses in 1994 to 1997 was associated with an incremental dosage regimen of melarsoprol. In multivariate analysis, after adjustment for treatment regimen, sex, residence, and trypanosomes in cerebrospinal fluid, postmelarsoprol relapses did not increase in Nioki, perhaps because 1) little drug pressure exists; 2) subtherapeutic doses have rarely been administered; 3) little potential exists for the preferential transmission of melarsoprol-resistant strains. Centers for Disease Control and Prevention 2005-06 /pmc/articles/PMC3367572/ /pubmed/15963288 http://dx.doi.org/10.3201/eid1106.050036 Text en https://creativecommons.org/licenses/by/4.0/This is a publication of the U.S. Government. This publication is in the public domain and is therefore without copyright. All text from this work may be reprinted freely. Use of these materials should be properly cited.
spellingShingle Research
Pépin, Jacques
Mpia, Bokelo
Trypanosomiasis Relapse after Melarsoprol Therapy, Democratic Republic of Congo, 1982–2001
title Trypanosomiasis Relapse after Melarsoprol Therapy, Democratic Republic of Congo, 1982–2001
title_full Trypanosomiasis Relapse after Melarsoprol Therapy, Democratic Republic of Congo, 1982–2001
title_fullStr Trypanosomiasis Relapse after Melarsoprol Therapy, Democratic Republic of Congo, 1982–2001
title_full_unstemmed Trypanosomiasis Relapse after Melarsoprol Therapy, Democratic Republic of Congo, 1982–2001
title_short Trypanosomiasis Relapse after Melarsoprol Therapy, Democratic Republic of Congo, 1982–2001
title_sort trypanosomiasis relapse after melarsoprol therapy, democratic republic of congo, 1982–2001
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3367572/
https://www.ncbi.nlm.nih.gov/pubmed/15963288
http://dx.doi.org/10.3201/eid1106.050036
work_keys_str_mv AT pepinjacques trypanosomiasisrelapseaftermelarsoproltherapydemocraticrepublicofcongo19822001
AT mpiabokelo trypanosomiasisrelapseaftermelarsoproltherapydemocraticrepublicofcongo19822001