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Community Prescribing and Resistant Streptococcus pneumoniae
We investigated the association between prescribing antimicrobial agents and antimicrobial resistance of Streptococcus pneumoniae among children with acute otitis media in southern Israel. During a 6-year period, all prescriptions of a sample of ≈20% of Jewish and Bedouin children <5 years of age...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Centers for Disease Control and Prevention
2005
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3367585/ https://www.ncbi.nlm.nih.gov/pubmed/15963276 http://dx.doi.org/10.3201/eid1106.050198 |
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author | Barkai, Galia Greenberg, David Givon-Lavi, Noga Dreifuss, Eli Vardy, Daniel Dagan, Ron |
author_facet | Barkai, Galia Greenberg, David Givon-Lavi, Noga Dreifuss, Eli Vardy, Daniel Dagan, Ron |
author_sort | Barkai, Galia |
collection | PubMed |
description | We investigated the association between prescribing antimicrobial agents and antimicrobial resistance of Streptococcus pneumoniae among children with acute otitis media in southern Israel. During a 6-year period, all prescriptions of a sample of ≈20% of Jewish and Bedouin children <5 years of age were recorded and all pneumococcal isolates from middle ear fluid were collected. Although antimicrobial drug use was significantly higher in Bedouin children, the proportion of S. pneumoniae isolates with penicillin MIC ≥1.0 μg/mL was significantly higher in Jewish children. In both populations, antimicrobial prescriptions were markedly reduced over time, especially for penicillins and erythromycin. In contrast, azithromycin prescriptions increased from 1998 to 2001 with a parallel increase in macrolide and multidrug resistance. Penicillin resistance was associated with macrolide resistance. These findings strongly suggest that azithromycin affects increased antimicrobial resistance, including multidrug resistance, in S. pneumoniae. |
format | Online Article Text |
id | pubmed-3367585 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2005 |
publisher | Centers for Disease Control and Prevention |
record_format | MEDLINE/PubMed |
spelling | pubmed-33675852012-06-07 Community Prescribing and Resistant Streptococcus pneumoniae Barkai, Galia Greenberg, David Givon-Lavi, Noga Dreifuss, Eli Vardy, Daniel Dagan, Ron Emerg Infect Dis Research We investigated the association between prescribing antimicrobial agents and antimicrobial resistance of Streptococcus pneumoniae among children with acute otitis media in southern Israel. During a 6-year period, all prescriptions of a sample of ≈20% of Jewish and Bedouin children <5 years of age were recorded and all pneumococcal isolates from middle ear fluid were collected. Although antimicrobial drug use was significantly higher in Bedouin children, the proportion of S. pneumoniae isolates with penicillin MIC ≥1.0 μg/mL was significantly higher in Jewish children. In both populations, antimicrobial prescriptions were markedly reduced over time, especially for penicillins and erythromycin. In contrast, azithromycin prescriptions increased from 1998 to 2001 with a parallel increase in macrolide and multidrug resistance. Penicillin resistance was associated with macrolide resistance. These findings strongly suggest that azithromycin affects increased antimicrobial resistance, including multidrug resistance, in S. pneumoniae. Centers for Disease Control and Prevention 2005-06 /pmc/articles/PMC3367585/ /pubmed/15963276 http://dx.doi.org/10.3201/eid1106.050198 Text en https://creativecommons.org/licenses/by/4.0/This is a publication of the U.S. Government. This publication is in the public domain and is therefore without copyright. All text from this work may be reprinted freely. Use of these materials should be properly cited. |
spellingShingle | Research Barkai, Galia Greenberg, David Givon-Lavi, Noga Dreifuss, Eli Vardy, Daniel Dagan, Ron Community Prescribing and Resistant Streptococcus pneumoniae |
title | Community Prescribing and Resistant Streptococcus pneumoniae |
title_full | Community Prescribing and Resistant Streptococcus pneumoniae |
title_fullStr | Community Prescribing and Resistant Streptococcus pneumoniae |
title_full_unstemmed | Community Prescribing and Resistant Streptococcus pneumoniae |
title_short | Community Prescribing and Resistant Streptococcus pneumoniae |
title_sort | community prescribing and resistant streptococcus pneumoniae |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3367585/ https://www.ncbi.nlm.nih.gov/pubmed/15963276 http://dx.doi.org/10.3201/eid1106.050198 |
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