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Visualization of Genomic Changes by Segmented Smoothing Using an L (0) Penalty
Copy number variations (CNV) and allelic imbalance in tumor tissue can show strong segmentation. Their graphical presentation can be enhanced by appropriate smoothing. Existing signal and scatterplot smoothers do not respect segmentation well. We present novel algorithms that use a penalty on the [I...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2012
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3367998/ https://www.ncbi.nlm.nih.gov/pubmed/22679492 http://dx.doi.org/10.1371/journal.pone.0038230 |