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CCN3 modulates bone turnover and is a novel regulator of skeletal metastasis

The CCN family of proteins is composed of six secreted proteins (CCN1-6), which are grouped together based on their structural similarity. These matricellular proteins are involved in a large spectrum of biological processes, ranging from development to disease. In this review, we focus on CCN3, a f...

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Detalles Bibliográficos
Autores principales: Ouellet, Véronique, Siegel, Peter M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Netherlands 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3368020/
https://www.ncbi.nlm.nih.gov/pubmed/22427255
http://dx.doi.org/10.1007/s12079-012-0161-7
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author Ouellet, Véronique
Siegel, Peter M.
author_facet Ouellet, Véronique
Siegel, Peter M.
author_sort Ouellet, Véronique
collection PubMed
description The CCN family of proteins is composed of six secreted proteins (CCN1-6), which are grouped together based on their structural similarity. These matricellular proteins are involved in a large spectrum of biological processes, ranging from development to disease. In this review, we focus on CCN3, a founding member of this family, and its role in regulating cells within the bone microenvironment. CCN3 impairs normal osteoblast differentiation through multiple mechanisms, which include the neutralization of pro-osteoblastogenic stimuli such as BMP and Wnt family signals or the activation of pathways that suppress osteoblastogenesis, such as Notch. In contrast, CCN3 is known to promote chondrocyte differentiation. Given these functions, it is not surprising that CCN3 has been implicated in the progression of primary bone cancers such as osteosarcoma, Ewing’s sarcoma and chondrosarcoma. More recently, emerging evidence suggests that CCN3 may also influence the ability of metastatic cancers to colonize and grow in bone.
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spelling pubmed-33680202012-06-14 CCN3 modulates bone turnover and is a novel regulator of skeletal metastasis Ouellet, Véronique Siegel, Peter M. J Cell Commun Signal Review The CCN family of proteins is composed of six secreted proteins (CCN1-6), which are grouped together based on their structural similarity. These matricellular proteins are involved in a large spectrum of biological processes, ranging from development to disease. In this review, we focus on CCN3, a founding member of this family, and its role in regulating cells within the bone microenvironment. CCN3 impairs normal osteoblast differentiation through multiple mechanisms, which include the neutralization of pro-osteoblastogenic stimuli such as BMP and Wnt family signals or the activation of pathways that suppress osteoblastogenesis, such as Notch. In contrast, CCN3 is known to promote chondrocyte differentiation. Given these functions, it is not surprising that CCN3 has been implicated in the progression of primary bone cancers such as osteosarcoma, Ewing’s sarcoma and chondrosarcoma. More recently, emerging evidence suggests that CCN3 may also influence the ability of metastatic cancers to colonize and grow in bone. Springer Netherlands 2012-03-18 2012-06 /pmc/articles/PMC3368020/ /pubmed/22427255 http://dx.doi.org/10.1007/s12079-012-0161-7 Text en © The Author(s) 2012 https://creativecommons.org/licenses/by/4.0/ This article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.
spellingShingle Review
Ouellet, Véronique
Siegel, Peter M.
CCN3 modulates bone turnover and is a novel regulator of skeletal metastasis
title CCN3 modulates bone turnover and is a novel regulator of skeletal metastasis
title_full CCN3 modulates bone turnover and is a novel regulator of skeletal metastasis
title_fullStr CCN3 modulates bone turnover and is a novel regulator of skeletal metastasis
title_full_unstemmed CCN3 modulates bone turnover and is a novel regulator of skeletal metastasis
title_short CCN3 modulates bone turnover and is a novel regulator of skeletal metastasis
title_sort ccn3 modulates bone turnover and is a novel regulator of skeletal metastasis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3368020/
https://www.ncbi.nlm.nih.gov/pubmed/22427255
http://dx.doi.org/10.1007/s12079-012-0161-7
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