Cargando…

Role of MMP-2 in the Regulation of IL-6/Stat3 Survival Signaling via Interaction With α5β1 Integrin in glioma

MMP-2 plays pivotal role in the degradation of extracellular matrix, and thereby enhances the invasive, proliferative and metastatic potential in cancer. Knockdown of MMP-2 using MMP-2 siRNA (pM) in human glioma xenograft cell lines 4910 and 5310 decreased cell proliferation compared to mock- and pS...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kesanakurti, Divya, Chetty, Chandramu, Dinh, Dzung H., Gujrati, Meena, Rao, Jasti S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2012
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3368064/ https://www.ncbi.nlm.nih.gov/pubmed/22349830 http://dx.doi.org/10.1038/onc.2012.52

Ejemplares similares

MMP-2 siRNA Inhibits Radiation-Enhanced Invasiveness in Glioma Cells
por: Badiga, Aruna Venkata, et al.
Publicado: (2011)

MMP-9, uPAR and Cathepsin B Silencing Downregulate Integrins in Human Glioma Xenograft Cells In Vitro and In Vivo in Nude Mice
por: Veeravalli, Krishna Kumar, et al.
Publicado: (2010)

MMP-2 mediates mesenchymal stem cell tropism towards medulloblastoma tumors
por: Bhoopathi, Praveen, et al.
Publicado: (2011)

Suppression of MMP-2 Attenuates TNF-α Induced NF-κB Activation and Leads to JNK Mediated Cell Death in Glioma
por: Kesanakurti, Divya, et al.
Publicado: (2011)

MMP-2 suppression abrogates irradiation-induced microtubule formation in endothelial cells by inhibiting αvβ3-mediated SDF-1/CXCR4 signaling
por: MADDIRELA, DILIP RAJASEKHAR, et al.
Publicado: (2013)

Regulation of DNA Repair Mechanism in Human Glioma Xenograft Cells both In Vitro and In Vivo in Nude Mice
por: Ponnala, Shivani, et al.
Publicado: (2011)

Metabolic remodeling precedes mitochondrial outer membrane permeabilization in human glioma xenograft cells
por: Ponnala, Shivani, et al.
Publicado: (2021)

Functional cooperativity by direct interaction between PAK4 and MMP-2 in the regulation of anoikis resistance, migration and invasion in glioma
por: Kesanakurti, D, et al.
Publicado: (2012)

Epigenetic Regulation of miRNA-211 by MMP-9 Governs Glioma Cell Apoptosis, Chemosensitivity and Radiosensitivity
por: Asuthkar, Swapna, et al.
Publicado: (2012)

Suppression of uPAR Retards Radiation-Induced Invasion and Migration Mediated by Integrin β1/FAK Signaling in Medulloblastoma
por: Nalla, Arun Kumar, et al.
Publicado: (2010)

Cathepsin B and uPAR Knockdown Inhibits Tumor-induced Angiogenesis by Modulating VEGF Expression in Glioma
por: Malla, Rama Rao, et al.
Publicado: (2011)

Specific knockdown of uPA/uPAR attenuates invasion in glioblastoma cells and xenografts by inhibition of cleavage and trafficking of Notch -1 receptor
por: Raghu, Hari, et al.
Publicado: (2011)

Downregulation of uPAR and Cathepsin B Induces Apoptosis via Regulation of Bcl-2 and Bax and Inhibition of the PI3K/Akt Pathway in Gliomas
por: Malla, Ramarao, et al.
Publicado: (2010)

Correction: Downregulation of uPAR and Cathepsin B Induces Apoptosis via Regulation of Bcl-2 and Bax and Inhibition of the PI3K/Akt Pathway in Gliomas
por: Malla, Ramarao, et al.
Publicado: (2014)

α3β1 integrin promotes radiation-induced migration of meningioma cells
por: Gogineni, Venkateswara Rao, et al.
Publicado: (2021)

Apoptosis Induced by Knockdown of uPAR and MMP-9 is Mediated by Inactivation of EGFR/STAT3 Signaling in Medulloblastoma
por: Kotipatruni, Ramaprasada Rao, et al.
Publicado: (2012)

Cord Blood Stem Cell-Mediated Induction of Apoptosis in Glioma Downregulates X-Linked Inhibitor of Apoptosis Protein (XIAP)
por: Dasari, Venkata Ramesh, et al.
Publicado: (2010)

Upregulation of PTEN in Glioma Cells by Cord Blood Mesenchymal Stem Cells Inhibits Migration via Downregulation of the PI3K/Akt Pathway
por: Dasari, Venkata Ramesh, et al.
Publicado: (2010)

uPAR and cathepsin B-mediated compartmentalization of JNK regulates the migration of glioma-initiating cells
por: Alapati, Kiranmai, et al.
Publicado: (2014)

Co-Depletion of Cathepsin B and uPAR Induces G0/G1 Arrest in Glioma via FOXO3a Mediated p27(Kip1) Upregulation
por: Gopinath, Sreelatha, et al.
Publicado: (2010)

Suppression of uPA and uPAR Attenuates Angiogenin Mediated Angiogenesis in Endothelial and Glioblastoma Cell Lines
por: Raghu, Hari, et al.
Publicado: (2010)

The role of MMP-9 in the anti-angiogenic effect of secreted protein acidic and rich in cysteine
por: Bhoopathi, P, et al.
Publicado: (2010)

MMP-9 and uPAR regulated glioma cell migration
por: Veeravalli, Krishna Kumar, et al.
Publicado: (2012)

Involvement of nitric oxide synthase in matrix metalloproteinase-9- and/or urokinase plasminogen activator receptor-mediated glioma cell migration
por: Zhuang, Thompson, et al.
Publicado: (2013)

Cord blood stem cells revert glioma stem cell EMT by down regulating transcriptional activation of Sox2 and Twist1
por: Velpula, Kiran Kumar, et al.
Publicado: (2011)

The secreted protein acidic and rich in cysteine (SPARC) induces endoplasmic reticulum stress leading to autophagy-mediated apoptosis in neuroblastoma
por: SAILAJA, G.S., et al.
Publicado: (2012)

Oncogenic role of p53 is suppressed by si-RNA bicistronic construct of uPA, uPAR and cathepsin-B in meningiomas both in vitro and in vivo
por: Gupta, Reshu, et al.
Publicado: (2021)

Temporal Regulation of Apoptotic and Anti-apoptotic Molecules After Middle Cerebral Artery Occlusion Followed by Reperfusion
por: Chelluboina, Bharath, et al.
Publicado: (2013)

uPAR and cathepsin B knockdown inhibits radiation-induced PKC integrated integrin signaling to the cytoskeleton of glioma-initiating cells
por: ALAPATI, KIRANMAI, et al.
Publicado: (2012)

Novel STAT binding elements mediate IL-6 regulation of MMP-1 and MMP-3
por: Cutler, Samuel J., et al.
Publicado: (2017)

Analysis of the expression and prognostic value of MT1-MMP, β1-integrin and YAP1 in glioma
por: Zhai, Yangyang, et al.
Publicado: (2022)

SPARC Overexpression Inhibits Cell Proliferation in Neuroblastoma and Is Partly Mediated by Tumor Suppressor Protein PTEN and AKT
por: Bhoopathi, Praveen, et al.
Publicado: (2012)

Tumor-associated soluble uPAR-directed endothelial cell motility and tumor angiogenesis
por: Rao, J S, et al.
Publicado: (2013)

A Novel Interaction of PAK4 with PPARγ to Regulate Nox1 and Radiation-Induced Epithelial-to-Mesenchymal Transition in Glioma
por: Kesanakurti, Divya, et al.
Publicado: (2017)

Integrin α6 signaling induces STAT3-TET3-mediated hydroxymethylation of genes critical for maintenance of glioma stem cells
por: Herrmann, Andreas, et al.
Publicado: (2019)

Integrin αvβ6-associated ERK2 mediates MMP-9 secretion in colon cancer cells
por: Gu, X, et al.
Publicado: (2002)

MMP7 Shedding of Syndecan-1 Facilitates Re-Epithelialization by Affecting α(2)β(1) Integrin Activation
por: Chen, Peter, et al.
Publicado: (2009)

β1 integrin and IL-3R coordinately regulate STAT5 activation and anchorage-dependent proliferation
por: Defilippi, Paola, et al.
Publicado: (2005)

Latent effects of fibronectin, α5β1 integrin, αVβ5 integrin and the cytoskeleton regulate pancreatic carcinoma cell IL-8 secretion
por: Lowrie, A G, et al.
Publicado: (2004)

Integrin α3 is overexpressed in glioma stem-like cells and promotes invasion
por: Nakada, M, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_peit6jv9pqop4lp4dvsjpbqkpj