A novel full-length isoform of murine pregnancy-specific glycoprotein 16 (psg16) is expressed in the brain but does not mediate murine coronavirus (MHV) entry

The mouse pregnancy-specific glycoprotein 16 (PSG16) has been reported to be an alternative receptor for mouse hepatitis virus (MHV), some strains of which cause encephalitis in mice lacking the canonical receptor CEACAM1a. The known isoforms of PSG16 are N-terminally truncated relative to other PSG...

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Detalles Bibliográficos
Autores principales: Phillips, Judith M., Kuo, I-Ting, Richardson, Chelsea, Weiss, Susan R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2012
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3368079/
https://www.ncbi.nlm.nih.gov/pubmed/22302612
http://dx.doi.org/10.1007/s13365-012-0081-6
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author Phillips, Judith M.
Kuo, I-Ting
Richardson, Chelsea
Weiss, Susan R.
author_facet Phillips, Judith M.
Kuo, I-Ting
Richardson, Chelsea
Weiss, Susan R.
author_sort Phillips, Judith M.
collection PubMed
description The mouse pregnancy-specific glycoprotein 16 (PSG16) has been reported to be an alternative receptor for mouse hepatitis virus (MHV), some strains of which cause encephalitis in mice lacking the canonical receptor CEACAM1a. The known isoforms of PSG16 are N-terminally truncated relative to other PSG family proteins and are expressed in neurons as well as in the placenta. We have cloned a novel full-length isoform of psg16 that is also expressed in the brain, placenta, and retina but, like the truncated form, lacks MHV receptor activity when expressed on 293T cells, suggesting that PSG16 does not mediate CEACAM1a-independent spread of MHV.
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spelling pubmed-33680792013-04-01 A novel full-length isoform of murine pregnancy-specific glycoprotein 16 (psg16) is expressed in the brain but does not mediate murine coronavirus (MHV) entry Phillips, Judith M. Kuo, I-Ting Richardson, Chelsea Weiss, Susan R. J Neurovirol Short Communication The mouse pregnancy-specific glycoprotein 16 (PSG16) has been reported to be an alternative receptor for mouse hepatitis virus (MHV), some strains of which cause encephalitis in mice lacking the canonical receptor CEACAM1a. The known isoforms of PSG16 are N-terminally truncated relative to other PSG family proteins and are expressed in neurons as well as in the placenta. We have cloned a novel full-length isoform of psg16 that is also expressed in the brain, placenta, and retina but, like the truncated form, lacks MHV receptor activity when expressed on 293T cells, suggesting that PSG16 does not mediate CEACAM1a-independent spread of MHV. Springer US 2012-02-03 2012 /pmc/articles/PMC3368079/ /pubmed/22302612 http://dx.doi.org/10.1007/s13365-012-0081-6 Text en © Journal of NeuroVirology, Inc. 2012 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Short Communication
Phillips, Judith M.
Kuo, I-Ting
Richardson, Chelsea
Weiss, Susan R.
A novel full-length isoform of murine pregnancy-specific glycoprotein 16 (psg16) is expressed in the brain but does not mediate murine coronavirus (MHV) entry
title A novel full-length isoform of murine pregnancy-specific glycoprotein 16 (psg16) is expressed in the brain but does not mediate murine coronavirus (MHV) entry
title_full A novel full-length isoform of murine pregnancy-specific glycoprotein 16 (psg16) is expressed in the brain but does not mediate murine coronavirus (MHV) entry
title_fullStr A novel full-length isoform of murine pregnancy-specific glycoprotein 16 (psg16) is expressed in the brain but does not mediate murine coronavirus (MHV) entry
title_full_unstemmed A novel full-length isoform of murine pregnancy-specific glycoprotein 16 (psg16) is expressed in the brain but does not mediate murine coronavirus (MHV) entry
title_short A novel full-length isoform of murine pregnancy-specific glycoprotein 16 (psg16) is expressed in the brain but does not mediate murine coronavirus (MHV) entry
title_sort novel full-length isoform of murine pregnancy-specific glycoprotein 16 (psg16) is expressed in the brain but does not mediate murine coronavirus (mhv) entry
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3368079/
https://www.ncbi.nlm.nih.gov/pubmed/22302612
http://dx.doi.org/10.1007/s13365-012-0081-6
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