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Targeting the Fanconi Anemia Pathway to Identify Tailored Anticancer Therapeutics

The Fanconi Anemia (FA) pathway consists of proteins involved in repairing DNA damage, including interstrand cross-links (ICLs). The pathway contains an upstream multiprotein core complex that mediates the monoubiquitylation of the FANCD2 and FANCI heterodimer, and a downstream pathway that converge...

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Detalles Bibliográficos
Autores principales:	Jenkins, Chelsea, Kan, Jenny, Hoatlin, Maureen E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi Publishing Corporation 2012
Materias:	Review Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3368156/ https://www.ncbi.nlm.nih.gov/pubmed/22693661 http://dx.doi.org/10.1155/2012/481583

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