Cargando…

microRNA-21 Governs TORC1 Activation in Renal Cancer Cell Proliferation and Invasion

Metastatic renal cancer manifests multiple signatures of gene expression. Deviation in expression of mature miRNAs has been linked to human cancers. Importance of miR-21 in renal cell carcinomas is proposed from profiling studies using tumor tissue samples. However, the role of miR-21 function in ca...

Descripción completa

Detalles Bibliográficos
Autores principales:	Dey, Nirmalya, Das, Falguni, Ghosh-Choudhury, Nandini, Mandal, Chandi Charan, Parekh, Dipen J., Block, Karen, Kasinath, Balakuntalam S., Abboud, Hanna E., Choudhury, Goutam Ghosh
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3368259/ https://www.ncbi.nlm.nih.gov/pubmed/22685542 http://dx.doi.org/10.1371/journal.pone.0037366

Ejemplares similares

TGFβ-Stimulated MicroRNA-21 Utilizes PTEN to Orchestrate AKT/mTORC1 Signaling for Mesangial Cell Hypertrophy and Matrix Expansion
por: Dey, Nirmalya, et al.
Publicado: (2012)

TGFβ-Induced Deptor Suppression Recruits mTORC1 and Not mTORC2 to Enhance Collagen I (α2) Gene Expression
por: Das, Falguni, et al.
Publicado: (2014)

Oncoprotein DJ-1 interacts with mTOR complexes to effect transcription factor Hif1α-dependent expression of collagen I (α2) during renal fibrosis
por: Das, Falguni, et al.
Publicado: (2022)

Akt2 causes TGFβ-induced deptor downregulation facilitating mTOR to drive podocyte hypertrophy and matrix protein expression
por: Das, Falguni, et al.
Publicado: (2018)

Rapamycin selectively alters serum chemistry in diabetic mice
por: Tabatabai-Mir, Hooman, et al.
Publicado: (2012)

Chloride channel accessory 1 integrates chloride channel activity and mTORC1 in aging‐related kidney injury
por: Lee, Hak Joo, et al.
Publicado: (2021)

Hydrogen sulfide to the rescue in obstructive kidney injury
por: Kasinath, Balakuntalam S.
Publicado: (2014)

Erk in Kidney Diseases
por: Feliers, Denis, et al.
Publicado: (2011)

Mammalian Target of Rapamycin Regulates Nox4-Mediated Podocyte Depletion in Diabetic Renal Injury
por: Eid, Assaad A., et al.
Publicado: (2013)

Tryptophan Metabolism in Patients With Chronic Kidney Disease Secondary to Type 2 Diabetes: Relationship to Inflammatory Markers
por: Debnath, Subrata, et al.
Publicado: (2017)

Nox4 is a Target for Tuberin Deficiency Syndrome
por: Shi, Qian, et al.
Publicado: (2018)

Proximal tubular epithelial insulin receptor mediates high-fat diet–induced kidney injury
por: Lee, Hak Joo, et al.
Publicado: (2021)

Regulation of Glomerular Endothelial Cell Proteoglycans by Glucose
por: Ha, Tae-Sun, et al.
Publicado: (2004)

Antineoplastic and Apoptotic Potential of Traditional Medicines Thymoquinone and Diosgenin in Squamous Cell Carcinoma
por: Das, Subhasis, et al.
Publicado: (2012)

Fatigue characteristics on dialysis and non-dialysis days in patients with chronic kidney failure on maintenance hemodialysis
por: Debnath, Subrata, et al.
Publicado: (2021)

A Molecular Analysis Provides Novel Insights into Androgen Receptor Signalling in Breast Cancer
por: Mehta, Jatin, et al.
Publicado: (2015)

Stabilization of HIF-2alpha through redox regulation of mTORC2 activation and initiation of mRNA translation
por: Nayak, Bijaya K., et al.
Publicado: (2012)

HIV-1 Promotes Renal Tubular Epithelial Cell Protein Synthesis: Role of mTOR Pathway
por: Rehman, Shabina, et al.
Publicado: (2012)

Foreign Bodies in the Ear and Nose
por: Banerji, Chandi Charan
Publicado: (1924)

Infection kinetics of Covid-19 and containment strategy
por: Chattopadhyay, Amit K, et al.
Publicado: (2021)

Power-laws in dog behavior may pave the way to predictive models: A pattern analysis study
por: Banerjee, Arunita, et al.
Publicado: (2021)

Differential expression of IL-6/IL-6R and MAO-A regulates invasion/angiogenesis in breast cancer
por: Bharti, Rashmi, et al.
Publicado: (2018)

Current scenario on adhesion to zirconia; surface pretreatments and resin cements: A systematic review
por: Chatterjee, Nirmalya, et al.
Publicado: (2022)

Vesicular (liposomal and nanoparticulated) delivery of curcumin: a comparative study on carbon tetrachloride–mediated oxidative hepatocellular damage in rat model
por: Choudhury, Somsubhra Thakur, et al.
Publicado: (2016)

Ubiquitination of Rheb governs growth factor-induced mTORC1 activation
por: Deng, Lu, et al.
Publicado: (2018)

Ethical Considerations of Mental Health Research Amidst COVID-19 Pandemic: Mitigating the Challenges
por: Choudhury, Shinjini, et al.
Publicado: (2020)

Biocontrol of larval mosquitoes by Acilius sulcatus (Coleoptera: Dytiscidae)
por: Chandra, Goutam, et al.
Publicado: (2008)

Numerical analysis of predatory potentiality of Toxorhynchites splendens against larval Aedes albopictus in laboratory and semi-field conditions
por: Malla, Rajesh Kumar, et al.
Publicado: (2023)

Evaluating adherence to government recommendations for post-exposure rabies vaccine among animal-bite victims: A hospital-based study in Bangladesh
por: Tamanna, Sadia, et al.
Publicado: (2023)

High Cholesterol Deteriorates Bone Health: New Insights into Molecular Mechanisms
por: Mandal, Chandi C.
Publicado: (2015)

Editorial: Cancer and Bone Metastasis
por: Mandal, Chandi C.
Publicado: (2019)

Complete polarization characterization of single plasmonic nanoparticle enabled by a novel Dark-field Mueller matrix spectroscopy system
por: Chandel, Shubham, et al.
Publicado: (2016)

mTORC2 controls cancer cell survival by modulating gluconeogenesis
por: Khan, MW, et al.
Publicado: (2015)

Achieving Energy Efficiency and Impact of SAR in a WBAN Through Optimal Placement of the Relay Node
por: Ghosh, B., et al.
Publicado: (2023)

Culture independent molecular analysis of bacterial communities in the mangrove sediment of Sundarban, India
por: Ghosh, Abhrajyoti, et al.
Publicado: (2010)

Tsc/mTORC1 signaling in oocytes governs the quiescence and activation of primordial follicles
por: Adhikari, Deepak, et al.
Publicado: (2010)

TIPE2 governs macrophage polarization via negative regulation of mTORC1
por: Jiang, Yuan, et al.
Publicado: (2018)

Resensitization of Akt Induced Docetaxel Resistance in Breast Cancer by ‘Iturin A’ a Lipopeptide Molecule from Marine Bacteria Bacillus megaterium
por: Dey, Goutam, et al.
Publicado: (2017)

Machine drawing with AutoCAD
por: Pohit, Goutam, et al.
Publicado: (2007)

Association between OGG1 Ser326Cys polymorphism and risk of upper aero-digestive tract and gastrointestinal cancers: a meta-analysis
por: Das, Sambuddha, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_50e439i08d0psgmfqt42s4hcjb