Activated Protein C Induces Endoplasmic Reticulum Stress and Attenuates Lipopolysaccharide-Induced Apoptosis Mediated by Glycogen Synthase Kinase-3β

This study investigated the relationship between antiapoptotic activities induced by activated protein C and endoplasmic reticulum stress. In this study, it was observed that activated protein C elicited a rise in glucose-regulated protein 78 and glycogen synthase kinase-3β and inhibited apoptosis i...

Descripción completa

Detalles Bibliográficos
Autores principales: Luo, Liang, Lv, Tangfeng, Wang, Qian, Zhang, Ting, Gu, Xiaoling, Xu, Feng, Song, Yong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3368528/
https://www.ncbi.nlm.nih.gov/pubmed/22690042
http://dx.doi.org/10.1155/2012/485279
_version_ 1782234966291120128
author Luo, Liang
Lv, Tangfeng
Wang, Qian
Zhang, Ting
Gu, Xiaoling
Xu, Feng
Song, Yong
author_facet Luo, Liang
Lv, Tangfeng
Wang, Qian
Zhang, Ting
Gu, Xiaoling
Xu, Feng
Song, Yong
author_sort Luo, Liang
collection PubMed
description This study investigated the relationship between antiapoptotic activities induced by activated protein C and endoplasmic reticulum stress. In this study, it was observed that activated protein C elicited a rise in glucose-regulated protein 78 and glycogen synthase kinase-3β and inhibited apoptosis in human umbilical vein endothelial cells induced by lipopolysaccharide. Calcium inhibition did not alter the antiapoptotic effect of activated protein C. The antiapoptotic efficiency of activated protein C was reduced in human umbilical vein endothelial cells following treatment with glycogen synthase kinase-3β-siRNA. In summary, activated protein C induced endoplasmic reticulum stress and attenuated lipopolysaccharide-induced human umbilical vein endothelial cell apoptosis mediated by glycogen synthase kinase-3β.
format Online
Article
Text
id pubmed-3368528
institution National Center for Biotechnology Information
language English
publishDate 2012
publisher Hindawi Publishing Corporation
record_format MEDLINE/PubMed
spelling pubmed-33685282012-06-11 Activated Protein C Induces Endoplasmic Reticulum Stress and Attenuates Lipopolysaccharide-Induced Apoptosis Mediated by Glycogen Synthase Kinase-3β Luo, Liang Lv, Tangfeng Wang, Qian Zhang, Ting Gu, Xiaoling Xu, Feng Song, Yong Mediators Inflamm Research Article This study investigated the relationship between antiapoptotic activities induced by activated protein C and endoplasmic reticulum stress. In this study, it was observed that activated protein C elicited a rise in glucose-regulated protein 78 and glycogen synthase kinase-3β and inhibited apoptosis in human umbilical vein endothelial cells induced by lipopolysaccharide. Calcium inhibition did not alter the antiapoptotic effect of activated protein C. The antiapoptotic efficiency of activated protein C was reduced in human umbilical vein endothelial cells following treatment with glycogen synthase kinase-3β-siRNA. In summary, activated protein C induced endoplasmic reticulum stress and attenuated lipopolysaccharide-induced human umbilical vein endothelial cell apoptosis mediated by glycogen synthase kinase-3β. Hindawi Publishing Corporation 2012 2012-05-28 /pmc/articles/PMC3368528/ /pubmed/22690042 http://dx.doi.org/10.1155/2012/485279 Text en Copyright © 2012 Liang Luo et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Luo, Liang
Lv, Tangfeng
Wang, Qian
Zhang, Ting
Gu, Xiaoling
Xu, Feng
Song, Yong
Activated Protein C Induces Endoplasmic Reticulum Stress and Attenuates Lipopolysaccharide-Induced Apoptosis Mediated by Glycogen Synthase Kinase-3β
title Activated Protein C Induces Endoplasmic Reticulum Stress and Attenuates Lipopolysaccharide-Induced Apoptosis Mediated by Glycogen Synthase Kinase-3β
title_full Activated Protein C Induces Endoplasmic Reticulum Stress and Attenuates Lipopolysaccharide-Induced Apoptosis Mediated by Glycogen Synthase Kinase-3β
title_fullStr Activated Protein C Induces Endoplasmic Reticulum Stress and Attenuates Lipopolysaccharide-Induced Apoptosis Mediated by Glycogen Synthase Kinase-3β
title_full_unstemmed Activated Protein C Induces Endoplasmic Reticulum Stress and Attenuates Lipopolysaccharide-Induced Apoptosis Mediated by Glycogen Synthase Kinase-3β
title_short Activated Protein C Induces Endoplasmic Reticulum Stress and Attenuates Lipopolysaccharide-Induced Apoptosis Mediated by Glycogen Synthase Kinase-3β
title_sort activated protein c induces endoplasmic reticulum stress and attenuates lipopolysaccharide-induced apoptosis mediated by glycogen synthase kinase-3β
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3368528/
https://www.ncbi.nlm.nih.gov/pubmed/22690042
http://dx.doi.org/10.1155/2012/485279
work_keys_str_mv AT luoliang activatedproteincinducesendoplasmicreticulumstressandattenuateslipopolysaccharideinducedapoptosismediatedbyglycogensynthasekinase3b
AT lvtangfeng activatedproteincinducesendoplasmicreticulumstressandattenuateslipopolysaccharideinducedapoptosismediatedbyglycogensynthasekinase3b
AT wangqian activatedproteincinducesendoplasmicreticulumstressandattenuateslipopolysaccharideinducedapoptosismediatedbyglycogensynthasekinase3b
AT zhangting activatedproteincinducesendoplasmicreticulumstressandattenuateslipopolysaccharideinducedapoptosismediatedbyglycogensynthasekinase3b
AT guxiaoling activatedproteincinducesendoplasmicreticulumstressandattenuateslipopolysaccharideinducedapoptosismediatedbyglycogensynthasekinase3b
AT xufeng activatedproteincinducesendoplasmicreticulumstressandattenuateslipopolysaccharideinducedapoptosismediatedbyglycogensynthasekinase3b
AT songyong activatedproteincinducesendoplasmicreticulumstressandattenuateslipopolysaccharideinducedapoptosismediatedbyglycogensynthasekinase3b

Ejemplares similares