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Antimicrobial and Anti-Inflammatory Activities of Pterygota macrocarpa and Cola gigantea (Sterculiaceae)

Pterygota macrocarpa and Cola gigantea are African medicinal plants used in traditional medicine for the treatment of sores, skin infections, and other inflammatory conditions including pains. This study therefore aims at investigating the antimicrobial properties of ethanol leaf and stem bark extra...

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Autores principales: Agyare, Christian, Koffuor, George Asumeng, Boamah, Vivian Etsiapa, Adu, Francis, Mensah, Kwesi Boadu, Adu-Amoah, Louis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3368549/
https://www.ncbi.nlm.nih.gov/pubmed/22690251
http://dx.doi.org/10.1155/2012/902394
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author Agyare, Christian
Koffuor, George Asumeng
Boamah, Vivian Etsiapa
Adu, Francis
Mensah, Kwesi Boadu
Adu-Amoah, Louis
author_facet Agyare, Christian
Koffuor, George Asumeng
Boamah, Vivian Etsiapa
Adu, Francis
Mensah, Kwesi Boadu
Adu-Amoah, Louis
author_sort Agyare, Christian
collection PubMed
description Pterygota macrocarpa and Cola gigantea are African medicinal plants used in traditional medicine for the treatment of sores, skin infections, and other inflammatory conditions including pains. This study therefore aims at investigating the antimicrobial properties of ethanol leaf and stem bark extracts of P. macrocarpa and C. gigantea using the agar diffusion and the micro-dilution techniques and also determining the anti-inflammatory properties of the extracts of these plants in carrageenan-induced foot edema in seven-day old chicks. The minimum inhibitory concentration of both ethanol leaf and bark extracts of P. macrocarpa against the test organisms was from 0.125 to 2.55 mg/mL and that of C. gigantea extracts was 0.125 to 2.75 mg/mL. Extracts with concentration of 50 mg/mL were most active against the test organisms according to the agar diffusion method. All the extracts of P. macrocarpa and C. gigantea at 30, 100, and 300 mg/kg body weight except ethanol leaf extract of C. gigantea exhibited significant anti-inflammatory effects (P ≤ 0.001).
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spelling pubmed-33685492012-06-11 Antimicrobial and Anti-Inflammatory Activities of Pterygota macrocarpa and Cola gigantea (Sterculiaceae) Agyare, Christian Koffuor, George Asumeng Boamah, Vivian Etsiapa Adu, Francis Mensah, Kwesi Boadu Adu-Amoah, Louis Evid Based Complement Alternat Med Research Article Pterygota macrocarpa and Cola gigantea are African medicinal plants used in traditional medicine for the treatment of sores, skin infections, and other inflammatory conditions including pains. This study therefore aims at investigating the antimicrobial properties of ethanol leaf and stem bark extracts of P. macrocarpa and C. gigantea using the agar diffusion and the micro-dilution techniques and also determining the anti-inflammatory properties of the extracts of these plants in carrageenan-induced foot edema in seven-day old chicks. The minimum inhibitory concentration of both ethanol leaf and bark extracts of P. macrocarpa against the test organisms was from 0.125 to 2.55 mg/mL and that of C. gigantea extracts was 0.125 to 2.75 mg/mL. Extracts with concentration of 50 mg/mL were most active against the test organisms according to the agar diffusion method. All the extracts of P. macrocarpa and C. gigantea at 30, 100, and 300 mg/kg body weight except ethanol leaf extract of C. gigantea exhibited significant anti-inflammatory effects (P ≤ 0.001). Hindawi Publishing Corporation 2012 2012-05-28 /pmc/articles/PMC3368549/ /pubmed/22690251 http://dx.doi.org/10.1155/2012/902394 Text en Copyright © 2012 Christian Agyare et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Agyare, Christian
Koffuor, George Asumeng
Boamah, Vivian Etsiapa
Adu, Francis
Mensah, Kwesi Boadu
Adu-Amoah, Louis
Antimicrobial and Anti-Inflammatory Activities of Pterygota macrocarpa and Cola gigantea (Sterculiaceae)
title Antimicrobial and Anti-Inflammatory Activities of Pterygota macrocarpa and Cola gigantea (Sterculiaceae)
title_full Antimicrobial and Anti-Inflammatory Activities of Pterygota macrocarpa and Cola gigantea (Sterculiaceae)
title_fullStr Antimicrobial and Anti-Inflammatory Activities of Pterygota macrocarpa and Cola gigantea (Sterculiaceae)
title_full_unstemmed Antimicrobial and Anti-Inflammatory Activities of Pterygota macrocarpa and Cola gigantea (Sterculiaceae)
title_short Antimicrobial and Anti-Inflammatory Activities of Pterygota macrocarpa and Cola gigantea (Sterculiaceae)
title_sort antimicrobial and anti-inflammatory activities of pterygota macrocarpa and cola gigantea (sterculiaceae)
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3368549/
https://www.ncbi.nlm.nih.gov/pubmed/22690251
http://dx.doi.org/10.1155/2012/902394
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