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The myofibroblast, multiple origins for major roles in normal and pathological tissue repair

Myofibroblasts differentiate, invade and repair injured tissues by secreting and organizing the extracellular matrix and by developing contractile forces. When tissues are damaged, tissue homeostasis must be re-established, and repair mechanisms have to rapidly provide harmonious mechanical tissue o...

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Autores principales: Micallef, Ludovic, Vedrenne, Nicolas, Billet, Fabrice, Coulomb, Bernard, Darby, Ian A, Desmoulière, Alexis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3368789/
https://www.ncbi.nlm.nih.gov/pubmed/23259712
http://dx.doi.org/10.1186/1755-1536-5-S1-S5
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author Micallef, Ludovic
Vedrenne, Nicolas
Billet, Fabrice
Coulomb, Bernard
Darby, Ian A
Desmoulière, Alexis
author_facet Micallef, Ludovic
Vedrenne, Nicolas
Billet, Fabrice
Coulomb, Bernard
Darby, Ian A
Desmoulière, Alexis
author_sort Micallef, Ludovic
collection PubMed
description Myofibroblasts differentiate, invade and repair injured tissues by secreting and organizing the extracellular matrix and by developing contractile forces. When tissues are damaged, tissue homeostasis must be re-established, and repair mechanisms have to rapidly provide harmonious mechanical tissue organization, a process essentially supported by (myo)fibroblasts. Under physiological conditions, the secretory and contractile activities of myofibroblasts are terminated when the repair is complete (scar formation) but the functionality of the tissue is only rarely perfectly restored. At the end of the normal repair process, myofibroblasts disappear by apoptosis but in pathological situations, myofibroblasts likely remain leading to excessive scarring. Myofibroblasts originate from different precursor cells, the major contribution being from local recruitment of connective tissue fibroblasts. However, local mesenchymal stem cells, bone marrow-derived mesenchymal stem cells and cells derived from an epithelial-mesenchymal transition process, may represent alternative sources of myofibroblasts when local fibroblasts are not able to satisfy the requirement for these cells during repair. These diverse cell types probably contribute to the appearance of myofibroblast subpopulations which show specific biological properties and which are important to understand in order to develop new therapeutic strategies for treatment of fibrotic and scarring diseases.
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spelling pubmed-33687892012-06-07 The myofibroblast, multiple origins for major roles in normal and pathological tissue repair Micallef, Ludovic Vedrenne, Nicolas Billet, Fabrice Coulomb, Bernard Darby, Ian A Desmoulière, Alexis Fibrogenesis Tissue Repair Proceedings Myofibroblasts differentiate, invade and repair injured tissues by secreting and organizing the extracellular matrix and by developing contractile forces. When tissues are damaged, tissue homeostasis must be re-established, and repair mechanisms have to rapidly provide harmonious mechanical tissue organization, a process essentially supported by (myo)fibroblasts. Under physiological conditions, the secretory and contractile activities of myofibroblasts are terminated when the repair is complete (scar formation) but the functionality of the tissue is only rarely perfectly restored. At the end of the normal repair process, myofibroblasts disappear by apoptosis but in pathological situations, myofibroblasts likely remain leading to excessive scarring. Myofibroblasts originate from different precursor cells, the major contribution being from local recruitment of connective tissue fibroblasts. However, local mesenchymal stem cells, bone marrow-derived mesenchymal stem cells and cells derived from an epithelial-mesenchymal transition process, may represent alternative sources of myofibroblasts when local fibroblasts are not able to satisfy the requirement for these cells during repair. These diverse cell types probably contribute to the appearance of myofibroblast subpopulations which show specific biological properties and which are important to understand in order to develop new therapeutic strategies for treatment of fibrotic and scarring diseases. BioMed Central 2012-06-06 /pmc/articles/PMC3368789/ /pubmed/23259712 http://dx.doi.org/10.1186/1755-1536-5-S1-S5 Text en Copyright ©2012 Micallef et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Proceedings
Micallef, Ludovic
Vedrenne, Nicolas
Billet, Fabrice
Coulomb, Bernard
Darby, Ian A
Desmoulière, Alexis
The myofibroblast, multiple origins for major roles in normal and pathological tissue repair
title The myofibroblast, multiple origins for major roles in normal and pathological tissue repair
title_full The myofibroblast, multiple origins for major roles in normal and pathological tissue repair
title_fullStr The myofibroblast, multiple origins for major roles in normal and pathological tissue repair
title_full_unstemmed The myofibroblast, multiple origins for major roles in normal and pathological tissue repair
title_short The myofibroblast, multiple origins for major roles in normal and pathological tissue repair
title_sort myofibroblast, multiple origins for major roles in normal and pathological tissue repair
topic Proceedings
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3368789/
https://www.ncbi.nlm.nih.gov/pubmed/23259712
http://dx.doi.org/10.1186/1755-1536-5-S1-S5
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