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Smyd3 regulates cancer cell phenotypes and catalyzes histone H4 lysine 5 methylation
Smyd3 is a lysine methyltransferase implicated in chromatin and cancer regulation. Here we show that Smyd3 catalyzes histone H4 methylation at lysine 5 (H4K5me). This novel histone methylation mark is detected in diverse cell types and its formation is attenuated by depletion of Smyd3 protein. Furth...
| Autores principales: | , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Landes Bioscience
2012
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3368817/ https://www.ncbi.nlm.nih.gov/pubmed/22419068 http://dx.doi.org/10.4161/epi.19506 |
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| author | Van Aller, Glenn S. Reynoird, Nicolas Barbash, Olena Huddleston, Michael Liu, Shichong Zmoos, Anne-Flore McDevitt, Patrick Sinnamon, Robert Le, BaoChau Mas, Gloria Annan, Roland Sage, Julien Garcia, Benjamin A. Tummino, Peter J. Gozani, Or Kruger, Ryan G. |
| author_facet | Van Aller, Glenn S. Reynoird, Nicolas Barbash, Olena Huddleston, Michael Liu, Shichong Zmoos, Anne-Flore McDevitt, Patrick Sinnamon, Robert Le, BaoChau Mas, Gloria Annan, Roland Sage, Julien Garcia, Benjamin A. Tummino, Peter J. Gozani, Or Kruger, Ryan G. |
| author_sort | Van Aller, Glenn S. |
| collection | PubMed |
| description | Smyd3 is a lysine methyltransferase implicated in chromatin and cancer regulation. Here we show that Smyd3 catalyzes histone H4 methylation at lysine 5 (H4K5me). This novel histone methylation mark is detected in diverse cell types and its formation is attenuated by depletion of Smyd3 protein. Further, Smyd3-driven cancer cell phenotypes require its enzymatic activity. Thus, Smyd3, via H4K5 methylation, provides a potential new link between chromatin dynamics and neoplastic disease. |
| format | Online Article Text |
| id | pubmed-3368817 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2012 |
| publisher | Landes Bioscience |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-33688172012-06-07 Smyd3 regulates cancer cell phenotypes and catalyzes histone H4 lysine 5 methylation Van Aller, Glenn S. Reynoird, Nicolas Barbash, Olena Huddleston, Michael Liu, Shichong Zmoos, Anne-Flore McDevitt, Patrick Sinnamon, Robert Le, BaoChau Mas, Gloria Annan, Roland Sage, Julien Garcia, Benjamin A. Tummino, Peter J. Gozani, Or Kruger, Ryan G. Epigenetics Brief Report Smyd3 is a lysine methyltransferase implicated in chromatin and cancer regulation. Here we show that Smyd3 catalyzes histone H4 methylation at lysine 5 (H4K5me). This novel histone methylation mark is detected in diverse cell types and its formation is attenuated by depletion of Smyd3 protein. Further, Smyd3-driven cancer cell phenotypes require its enzymatic activity. Thus, Smyd3, via H4K5 methylation, provides a potential new link between chromatin dynamics and neoplastic disease. Landes Bioscience 2012-04-01 /pmc/articles/PMC3368817/ /pubmed/22419068 http://dx.doi.org/10.4161/epi.19506 Text en Copyright © 2012 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited. |
| spellingShingle | Brief Report Van Aller, Glenn S. Reynoird, Nicolas Barbash, Olena Huddleston, Michael Liu, Shichong Zmoos, Anne-Flore McDevitt, Patrick Sinnamon, Robert Le, BaoChau Mas, Gloria Annan, Roland Sage, Julien Garcia, Benjamin A. Tummino, Peter J. Gozani, Or Kruger, Ryan G. Smyd3 regulates cancer cell phenotypes and catalyzes histone H4 lysine 5 methylation |
| title | Smyd3 regulates cancer cell phenotypes and catalyzes histone H4 lysine 5 methylation |
| title_full | Smyd3 regulates cancer cell phenotypes and catalyzes histone H4 lysine 5 methylation |
| title_fullStr | Smyd3 regulates cancer cell phenotypes and catalyzes histone H4 lysine 5 methylation |
| title_full_unstemmed | Smyd3 regulates cancer cell phenotypes and catalyzes histone H4 lysine 5 methylation |
| title_short | Smyd3 regulates cancer cell phenotypes and catalyzes histone H4 lysine 5 methylation |
| title_sort | smyd3 regulates cancer cell phenotypes and catalyzes histone h4 lysine 5 methylation |
| topic | Brief Report |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3368817/ https://www.ncbi.nlm.nih.gov/pubmed/22419068 http://dx.doi.org/10.4161/epi.19506 |
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