Jacaranone Induces Apoptosis in Melanoma Cells via ROS-Mediated Downregulation of Akt and p38 MAPK Activation and Displays Antitumor Activity In Vivo

BACKGROUND: Malignant melanoma is a deadly type of metastatic skin cancer with increased incidence over the past 30 years. Despite the advanced knowledge on the biology, immunobiology and molecular genetics of melanoma, the alternatives of treatment are limited with poor prognosis. On clinical trial...

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Detalles Bibliográficos
Autores principales: Massaoka, Mariana H., Matsuo, Alisson L., Figueiredo, Carlos R., Farias, Camyla F., Girola, Natália, Arruda, Denise C., Scutti, Jorge A. B., Romoff, Paulete, Favero, Oriana A., Ferreira, Marcelo J. P., Lago, João H. G., Travassos, Luiz R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3368838/
https://www.ncbi.nlm.nih.gov/pubmed/22701695
http://dx.doi.org/10.1371/journal.pone.0038698

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3368838/
https://www.ncbi.nlm.nih.gov/pubmed/22701695
http://dx.doi.org/10.1371/journal.pone.0038698

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