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Combined Blockade of ADP Receptors and PI3-Kinase p110β Fully Prevents Platelet and Leukocyte Activation during Hypothermic Extracorporeal Circulation

Extracorporeal circulation (ECC) and hypothermia are used to maintain stable circulatory parameters and improve the ischemia tolerance of patients in cardiac surgery. However, ECC and hypothermia induce activation mechanisms in platelets and leukocytes, which are mediated by the platelet agonist ADP...

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Detalles Bibliográficos
Autores principales:	Krajewski, Stefanie, Kurz, Julia, Geisler, Tobias, Peter, Karlheinz, Wendel, Hans Peter, Straub, Andreas
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3368839/ https://www.ncbi.nlm.nih.gov/pubmed/22701645 http://dx.doi.org/10.1371/journal.pone.0038455

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