Defining and Detecting Crossover-Interference Mutants in Yeast

The analysis of crossover interference in many creatures is complicated by the presence of two kinds of crossovers, interfering and noninterfering. In such creatures, the values of the traditional indicators of interference are subject not only to the strength of interference but also to the relativ...

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Detalles Bibliográficos
Autor principal: Stahl, Frank
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3368871/
https://www.ncbi.nlm.nih.gov/pubmed/22701650
http://dx.doi.org/10.1371/journal.pone.0038476
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author Stahl, Frank
author_facet Stahl, Frank
author_sort Stahl, Frank
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description The analysis of crossover interference in many creatures is complicated by the presence of two kinds of crossovers, interfering and noninterfering. In such creatures, the values of the traditional indicators of interference are subject not only to the strength of interference but also to the relative frequencies of crossing over contributed by the two kinds. We formalize the relationship among these variables and illustrate the possibilities and limitations of classical interference analysis with meiotic tetrad data from wild-type Saccharomyces cerevisiae and from mlh1 and ndj1 mutants.
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spelling pubmed-33688712012-06-13 Defining and Detecting Crossover-Interference Mutants in Yeast Stahl, Frank PLoS One Research Article The analysis of crossover interference in many creatures is complicated by the presence of two kinds of crossovers, interfering and noninterfering. In such creatures, the values of the traditional indicators of interference are subject not only to the strength of interference but also to the relative frequencies of crossing over contributed by the two kinds. We formalize the relationship among these variables and illustrate the possibilities and limitations of classical interference analysis with meiotic tetrad data from wild-type Saccharomyces cerevisiae and from mlh1 and ndj1 mutants. Public Library of Science 2012-06-06 /pmc/articles/PMC3368871/ /pubmed/22701650 http://dx.doi.org/10.1371/journal.pone.0038476 Text en Frank Stahl. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Stahl, Frank
Defining and Detecting Crossover-Interference Mutants in Yeast
title Defining and Detecting Crossover-Interference Mutants in Yeast
title_full Defining and Detecting Crossover-Interference Mutants in Yeast
title_fullStr Defining and Detecting Crossover-Interference Mutants in Yeast
title_full_unstemmed Defining and Detecting Crossover-Interference Mutants in Yeast
title_short Defining and Detecting Crossover-Interference Mutants in Yeast
title_sort defining and detecting crossover-interference mutants in yeast
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3368871/
https://www.ncbi.nlm.nih.gov/pubmed/22701650
http://dx.doi.org/10.1371/journal.pone.0038476
work_keys_str_mv AT stahlfrank defininganddetectingcrossoverinterferencemutantsinyeast

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