Cargando…

Impaired LDL Receptor-Related Protein 1 Translocation Correlates with Improved Dyslipidemia and Atherosclerosis in apoE-Deficient Mice

OBJECTIVE: Determination of the in vivo significance of LDL receptor-related protein 1 (LRP1) dysfunction on lipid metabolism and atherosclerosis development in absence of its main ligand apoE. METHODS AND RESULTS: LRP1 knock-in mice carrying an inactivating mutation in the NPxYxxL motif were crosse...

Descripción completa

Detalles Bibliográficos
Autores principales:	Gordts, Philip L.S.M., Bartelt, Alexander, Nilsson, Stefan K., Annaert, Wim, Christoffersen, Christina, Nielsen, Lars Bo, Heeren, Joerg, Roebroek, Anton J.M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3368875/ https://www.ncbi.nlm.nih.gov/pubmed/22701627 http://dx.doi.org/10.1371/journal.pone.0038330

Ejemplares similares

Apolipoprotein E4 Exaggerates Diabetic Dyslipidemia and Atherosclerosis in Mice Lacking the LDL Receptor
por: Johnson, Lance A., et al.
Publicado: (2011)

Atherosclerosis, inflammation and lipoprotein glomerulopathy in kidneys of apoE(-/-)/LDL(-/- )double knockout mice
por: Langheinrich, Alexander C, et al.
Publicado: (2010)

Brown fat activation reduces hypercholesterolaemia and protects from atherosclerosis development
por: Berbée, Jimmy F. P., et al.
Publicado: (2015)

The adaptor protein PID1 regulates receptor-dependent endocytosis of postprandial triglyceride-rich lipoproteins
por: Fischer, Alexander W., et al.
Publicado: (2018)

Silence of TRIB3 Suppresses Atherosclerosis and Stabilizes Plaques in Diabetic ApoE(−/−)/LDL Receptor(−/−) Mice
por: Wang, Zhi-hao, et al.
Publicado: (2012)

An Essential Role for Diet in Exercise-Mediated Protection against Dyslipidemia, Inflammation and Atherosclerosis in ApoE-/- Mice
por: Cesar, Liliana, et al.
Publicado: (2011)

ABCC6 deficiency promotes dyslipidemia and atherosclerosis
por: Brampton, Christopher, et al.
Publicado: (2021)

Antibodies against apoB100 peptide 210 inhibit atherosclerosis in apoE(-/-) mice
por: Dunér, Pontus, et al.
Publicado: (2021)

ApoB/ApoA-I ratio is independently associated with carotid atherosclerosis in type 2 diabetes mellitus with well-controlled LDL cholesterol levels
por: Jun, Ji Eun, et al.
Publicado: (2018)

Regulation of plasma LDL: the apoB paradigm
por: Sniderman, Allan D., et al.
Publicado: (2009)

TAP1-Deficiency Does Not Alter Atherosclerosis Development in Apoe (−/−) Mice
por: Kolbus, Daniel, et al.
Publicado: (2012)

ALERT-LDL: adherence to guidelines in the treatment of patients with dyslipidemia
por: Bosso, Giorgio, et al.
Publicado: (2021)

Cannabinoid type 1 receptor inverse agonism attenuates dyslipidemia and atherosclerosis in APOE∗3-Leiden.CETP mice
por: van Eenige, Robin, et al.
Publicado: (2021)

Mutation in the distal NPxY motif of LRP1 alleviates dietary cholesterol-induced dyslipidemia and tissue inflammation
por: Jaeschke, Anja, et al.
Publicado: (2020)

Amygdalin ameliorates the progression of atherosclerosis in LDL receptor-deficient mice
por: Lv, Jianzhen, et al.
Publicado: (2017)

Interventional hepatic apoC-III knockdown improves atherosclerotic plaque stability and remodeling by triglyceride lowering
por: Ramms, Bastian, et al.
Publicado: (2022)

Atherosclerosis: visualising oxidised LDL in zebrafish
Publicado: (2012)

LOX-1, OxLDL, and Atherosclerosis
por: Pirillo, Angela, et al.
Publicado: (2013)

Recycling the LDL receptor to combat atherosclerosis
por: Vos, Dyonne, et al.
Publicado: (2018)

Cannabinoid Receptor 2 Deficiency in Haematopoietic cells Aggravates Early Atherosclerosis in LDL Receptor Deficient Mice
por: Delsing, Dianne J.M, et al.
Publicado: (2011)

Novel circulating lipid measurements for current dyslipidemias in non-treated patients undergoing coronary angiography: PCSK9, apoC3 and sdLDL-C
por: Li, Sha, et al.
Publicado: (2016)

Zebrafish Models for Dyslipidemia and Atherosclerosis Research
por: Schlegel, Amnon
Publicado: (2016)

Dyslipidemia-Induced Neuropathy in Mice: The Role of oxLDL/LOX-1
por: Vincent, Andrea M., et al.
Publicado: (2009)

Endothelial Function in Dyslipidemia: Roles of LDL-Cholesterol, HDL-Cholesterol and Triglycerides
por: Higashi, Yukihito
Publicado: (2023)

Hyperhomocysteinemia independently causes and promotes atherosclerosis in LDL receptor-deficient mice
por: Guo, Hang-Yuan, et al.
Publicado: (2014)

The APOE(∗)3-Leiden Heterozygous Glucokinase Knockout Mouse as Novel Translational Disease Model for Type 2 Diabetes, Dyslipidemia, and Diabetic Atherosclerosis
por: Pouwer, Marianne G., et al.
Publicado: (2019)

APOE Molecular Spectrum in a French Cohort with Primary Dyslipidemia
por: Abou Khalil, Yara, et al.
Publicado: (2022)

LDL-Cholesterol and Platelets: Insights into Their Interactions in Atherosclerosis
por: Gąsecka, Aleksandra, et al.
Publicado: (2021)

New Therapeutic Approaches to the Treatment of Dyslipidemia 2: LDL-C and Lp(a)
por: Kim, Kyung An, et al.
Publicado: (2023)

ApoD Mediates Binding of HDL to LDL and to Growing T24 Carcinoma
por: Braesch-Andersen, Sten, et al.
Publicado: (2014)

LDL cholesterol is associated with higher AD neuropathology burden independent of APOE
por: Wingo, Aliza P, et al.
Publicado: (2022)

T Cells in Atherosclerosis in Ldlr−/− and Apoe−/− Mice
por: Getz, Godfrey S., et al.
Publicado: (2018)

A Novel Perspective on the ApoM-S1P Axis, Highlighting the Metabolism of ApoM and Its Role in Liver Fibrosis and Neuroinflammation
por: Hajny, Stefan, et al.
Publicado: (2017)

Augmented Atherogenesis in LDL Receptor Deficient Mice Lacking Both Macrophage ABCA1 and ApoE
por: Lammers, Bart, et al.
Publicado: (2011)

Comparison of Framingham risk score and pooled cohort equations for the prediction of coronary atherosclerosis in patients who meet the target LDL-C level of Korean dyslipidemia guideline
por: Kim, Su Bin, et al.
Publicado: (2022)

Thrombin inhibition by dabigatran attenuates atherosclerosis in ApoE deficient mice
por: Pingel, Simon, et al.
Publicado: (2014)

Genetic Dissection of Tissue-Specific Apolipoprotein E Function for Hypercholesterolemia and Diet-Induced Obesity
por: Wagner, Tobias, et al.
Publicado: (2015)

Effect of alirocumab dose increase on LDL lowering and lipid goal attainment in patients with dyslipidemia
por: Kastelein, John J.P., et al.
Publicado: (2017)

The LDL-C/Apo B predicts coronary atherosclerotic heart disease in non-diabetic patients without high LDL-C
por: Jung, Hae Won, et al.
Publicado: (2023)

New insight into dyslipidemia‐induced cellular senescence in atherosclerosis
por: Xiang, Qunyan, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_u1p1l8im595vt3s3a3unhfghlj