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Congenital talipes equinovarus: an epidemiological study in Sicily

BACKGROUND AND PURPOSE: Congenital talipes equinovarus (clubfoot) can present in 2 forms: “syndromic”, in which other malformations exist, and the more common “idiopathic” form, where there are no other associated malformations. We analyzed the epidemiology of congenital talipes equinovarus in the S...

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Autores principales: Pavone, Vito, Bianca, Sebastiano, Grosso, Giuseppe, Pavone, Piero, Mistretta, Antonio, Longo, Maria Roberta, Marino, Silvia, Sessa, Giuseppe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Informa Healthcare 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3369158/
https://www.ncbi.nlm.nih.gov/pubmed/22489891
http://dx.doi.org/10.3109/17453674.2012.678797
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author Pavone, Vito
Bianca, Sebastiano
Grosso, Giuseppe
Pavone, Piero
Mistretta, Antonio
Longo, Maria Roberta
Marino, Silvia
Sessa, Giuseppe
author_facet Pavone, Vito
Bianca, Sebastiano
Grosso, Giuseppe
Pavone, Piero
Mistretta, Antonio
Longo, Maria Roberta
Marino, Silvia
Sessa, Giuseppe
author_sort Pavone, Vito
collection PubMed
description BACKGROUND AND PURPOSE: Congenital talipes equinovarus (clubfoot) can present in 2 forms: “syndromic”, in which other malformations exist, and the more common “idiopathic” form, where there are no other associated malformations. We analyzed the epidemiology of congenital talipes equinovarus in the Sicilian population, looking for potential etiological factors. PATIENTS AND METHODS: Among the 801,324 live births recorded between January 1991 and December 2004, 827 cases were registered (560 males; M/F sex ratio: 2.1). Control infants were randomly selected from a historical cohort of live births without any major congenital malformations. RESULTS: A positive family history of clubfoot, gender, and maternal smoking were found to be risk factors for clubfoot. Patients with clubfoot were born most frequently during the period January–March. No association was found between clubfoot and reproductive history, peri-conceptional maternal drug exposure, maternal education, or ethnicity. INTERPRETATION: Our findings emphasize the importance of birth defects surveillance programs and their usefulness in investigating potential risk factors.
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spelling pubmed-33691582012-06-11 Congenital talipes equinovarus: an epidemiological study in Sicily Pavone, Vito Bianca, Sebastiano Grosso, Giuseppe Pavone, Piero Mistretta, Antonio Longo, Maria Roberta Marino, Silvia Sessa, Giuseppe Acta Orthop Article BACKGROUND AND PURPOSE: Congenital talipes equinovarus (clubfoot) can present in 2 forms: “syndromic”, in which other malformations exist, and the more common “idiopathic” form, where there are no other associated malformations. We analyzed the epidemiology of congenital talipes equinovarus in the Sicilian population, looking for potential etiological factors. PATIENTS AND METHODS: Among the 801,324 live births recorded between January 1991 and December 2004, 827 cases were registered (560 males; M/F sex ratio: 2.1). Control infants were randomly selected from a historical cohort of live births without any major congenital malformations. RESULTS: A positive family history of clubfoot, gender, and maternal smoking were found to be risk factors for clubfoot. Patients with clubfoot were born most frequently during the period January–March. No association was found between clubfoot and reproductive history, peri-conceptional maternal drug exposure, maternal education, or ethnicity. INTERPRETATION: Our findings emphasize the importance of birth defects surveillance programs and their usefulness in investigating potential risk factors. Informa Healthcare 2012-06 2012-06-04 /pmc/articles/PMC3369158/ /pubmed/22489891 http://dx.doi.org/10.3109/17453674.2012.678797 Text en Copyright: © Nordic Orthopaedic Federation http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the source is credited.
spellingShingle Article
Pavone, Vito
Bianca, Sebastiano
Grosso, Giuseppe
Pavone, Piero
Mistretta, Antonio
Longo, Maria Roberta
Marino, Silvia
Sessa, Giuseppe
Congenital talipes equinovarus: an epidemiological study in Sicily
title Congenital talipes equinovarus: an epidemiological study in Sicily
title_full Congenital talipes equinovarus: an epidemiological study in Sicily
title_fullStr Congenital talipes equinovarus: an epidemiological study in Sicily
title_full_unstemmed Congenital talipes equinovarus: an epidemiological study in Sicily
title_short Congenital talipes equinovarus: an epidemiological study in Sicily
title_sort congenital talipes equinovarus: an epidemiological study in sicily
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3369158/
https://www.ncbi.nlm.nih.gov/pubmed/22489891
http://dx.doi.org/10.3109/17453674.2012.678797
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