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Pulmonary Lymphangitic Carcinomatosis due to Renal Cell Carcinoma
Renal cell carcinoma is an aggressive disease with a high rate of mortality. It is known to metastasize to the lung, liver, bone and brain. However, manifestation through lymphatic spread to the lungs is rare. Lymphangitic carcinomatosis is commonly observed in malignancies of the breast, lung, panc...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
S. Karger AG
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3369259/ https://www.ncbi.nlm.nih.gov/pubmed/22679431 http://dx.doi.org/10.1159/000339126 |
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author | Guddati, Achuta K. Marak, Creticus P. |
author_facet | Guddati, Achuta K. Marak, Creticus P. |
author_sort | Guddati, Achuta K. |
collection | PubMed |
description | Renal cell carcinoma is an aggressive disease with a high rate of mortality. It is known to metastasize to the lung, liver, bone and brain. However, manifestation through lymphatic spread to the lungs is rare. Lymphangitic carcinomatosis is commonly observed in malignancies of the breast, lung, pancreas, colon and cervix. It is unusual to observe lymphangitic carcinomatosis of the lungs due to renal cell carcinoma. Lymphangitic carcinomatosis of the lungs may result in severe respiratory distress and may be the direct cause of death. Currently, there are no known modalities of preventing or slowing lymphangitic carcinomatosis besides treating the primary tumor. However, early detection may change the course of the disease and may prolong survival. This is compounded by the difficulty involved in diagnosing lymphangitic carcinomatosis of the lung which frequently involves lung biopsy. Immunohistochemical studies are often used in conjunction with regular histochemistry in ascertaining the primary tumor and in differentiating it from pulmonary metastasis. In this case report, we describe the presentation and clinical course of renal cell carcinoma in a patient which manifested as lymphangitis carcinomatosa of the lungs. The patient underwent surgical resection of the primary tumor with lymph node resection but presented with a fulminant lymphangitic carcinomatosis of the lungs within two weeks. Immunohistochemistry of the tissue obtained by the biopsy confirmed the diagnosis which was subsequently corroborated during his autopsy. This case illustrates the necessity of an urgent follow-up of chemotherapy and immunotherapy in such patients. |
format | Online Article Text |
id | pubmed-3369259 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | S. Karger AG |
record_format | MEDLINE/PubMed |
spelling | pubmed-33692592012-06-07 Pulmonary Lymphangitic Carcinomatosis due to Renal Cell Carcinoma Guddati, Achuta K. Marak, Creticus P. Case Rep Oncol Published online: May, 2012 Renal cell carcinoma is an aggressive disease with a high rate of mortality. It is known to metastasize to the lung, liver, bone and brain. However, manifestation through lymphatic spread to the lungs is rare. Lymphangitic carcinomatosis is commonly observed in malignancies of the breast, lung, pancreas, colon and cervix. It is unusual to observe lymphangitic carcinomatosis of the lungs due to renal cell carcinoma. Lymphangitic carcinomatosis of the lungs may result in severe respiratory distress and may be the direct cause of death. Currently, there are no known modalities of preventing or slowing lymphangitic carcinomatosis besides treating the primary tumor. However, early detection may change the course of the disease and may prolong survival. This is compounded by the difficulty involved in diagnosing lymphangitic carcinomatosis of the lung which frequently involves lung biopsy. Immunohistochemical studies are often used in conjunction with regular histochemistry in ascertaining the primary tumor and in differentiating it from pulmonary metastasis. In this case report, we describe the presentation and clinical course of renal cell carcinoma in a patient which manifested as lymphangitis carcinomatosa of the lungs. The patient underwent surgical resection of the primary tumor with lymph node resection but presented with a fulminant lymphangitic carcinomatosis of the lungs within two weeks. Immunohistochemistry of the tissue obtained by the biopsy confirmed the diagnosis which was subsequently corroborated during his autopsy. This case illustrates the necessity of an urgent follow-up of chemotherapy and immunotherapy in such patients. S. Karger AG 2012-05-15 /pmc/articles/PMC3369259/ /pubmed/22679431 http://dx.doi.org/10.1159/000339126 Text en Copyright © 2012 by S. Karger AG, Basel http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Noncommercial-No-Derivative-Works License (http://creativecommons.org/licenses/by-nc-nd/3.0/). Users may download, print and share this work on the Internet for noncommercial purposes only, provided the original work is properly cited, and a link to the original work on http://www.karger.com and the terms of this license are included in any shared versions. |
spellingShingle | Published online: May, 2012 Guddati, Achuta K. Marak, Creticus P. Pulmonary Lymphangitic Carcinomatosis due to Renal Cell Carcinoma |
title | Pulmonary Lymphangitic Carcinomatosis due to Renal Cell Carcinoma |
title_full | Pulmonary Lymphangitic Carcinomatosis due to Renal Cell Carcinoma |
title_fullStr | Pulmonary Lymphangitic Carcinomatosis due to Renal Cell Carcinoma |
title_full_unstemmed | Pulmonary Lymphangitic Carcinomatosis due to Renal Cell Carcinoma |
title_short | Pulmonary Lymphangitic Carcinomatosis due to Renal Cell Carcinoma |
title_sort | pulmonary lymphangitic carcinomatosis due to renal cell carcinoma |
topic | Published online: May, 2012 |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3369259/ https://www.ncbi.nlm.nih.gov/pubmed/22679431 http://dx.doi.org/10.1159/000339126 |
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