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Association of Cardiac Baroreflex Sensitivity with Blood Pressure Transients: Influence of Sex and Menopausal Status

The magnitude of decrease in blood pressure (BP) during a vasoactive drug bolus may be associated with the calculated baroreflex sensitivity (BRS). The purpose of the present study was to evaluate whether sympathetic and/or cardiac BRS relates to the extent of change in BP and whether this was alter...

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Main Authors: Barnes, Jill N., Matzek, Luke J., Charkoudian, Nisha, Joyner, Michael J., Curry, Timothy B., Hart, Emma C.
Format: Online Article Text
Language:English
Published: Frontiers Research Foundation 2012
Subjects:
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3369369/
https://www.ncbi.nlm.nih.gov/pubmed/22701103
http://dx.doi.org/10.3389/fphys.2012.00187
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author Barnes, Jill N.
Matzek, Luke J.
Charkoudian, Nisha
Joyner, Michael J.
Curry, Timothy B.
Hart, Emma C.
author_facet Barnes, Jill N.
Matzek, Luke J.
Charkoudian, Nisha
Joyner, Michael J.
Curry, Timothy B.
Hart, Emma C.
author_sort Barnes, Jill N.
collection PubMed
description The magnitude of decrease in blood pressure (BP) during a vasoactive drug bolus may be associated with the calculated baroreflex sensitivity (BRS). The purpose of the present study was to evaluate whether sympathetic and/or cardiac BRS relates to the extent of change in BP and whether this was altered by sex hormones. Fifty-one young women (27 ± 1 years), 14 older women (58 ± 1 years), and 36 young men (27 ± 1 years) were studied. Heart rate, BP, and muscle sympathetic nerve activity (MSNA) were monitored. Sympathetic BRS was analyzed using the slope of the MSNA-diastolic blood pressure (DBP) relationship and cardiac BRS was analyzed using the R–R interval-systolic blood pressure (SBP) relationship. Young women and men had similar mean arterial pressures (MAP, 91 ± 1 vs. 90 ± 1 mmHg), cardiac BRS (19 ± 1 vs. 21 ± 2 ms/mmHg), and sympathetic BRS (−6 ± 1 vs. −7 ± 1 AU/beat/mmHg), respectively. Older women had higher MAP (104 ± 4 mmHg, p < 0.05) and lower cardiac BRS (7 ± 1 ms/mmHg, p < 0.05), but similar sympathetic BRS (−8 ± 1 AU/beat/mmHg). There was no association between BP transients with either cardiac or sympathetic BRS in young women. In the older women, the drop in SBP, DBP, and MAP were associated with cardiac BRS (r = 0.60, r = 0.59, and r = 0.70, respectively; p < 0.05), but not sympathetic BRS. The decrease in SBP was positively related to cardiac BRS in young men (r = 0.41; p < 0.05). However, there was no relationship between the decrease in BP and sympathetic BRS. This indicates that older women and young men with low cardiac BRS have larger transients in BP during nitroprusside. This suggests a more prominent role for cardiac (as opposed to sympathetic) BRS in responding to acute BP changes in young men and older women. The fact that these relationships do not exist in young women suggest that the female sex hormones influence baroreflex responses.
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spelling pubmed-33693692012-06-13 Association of Cardiac Baroreflex Sensitivity with Blood Pressure Transients: Influence of Sex and Menopausal Status Barnes, Jill N. Matzek, Luke J. Charkoudian, Nisha Joyner, Michael J. Curry, Timothy B. Hart, Emma C. Front Physiol Physiology The magnitude of decrease in blood pressure (BP) during a vasoactive drug bolus may be associated with the calculated baroreflex sensitivity (BRS). The purpose of the present study was to evaluate whether sympathetic and/or cardiac BRS relates to the extent of change in BP and whether this was altered by sex hormones. Fifty-one young women (27 ± 1 years), 14 older women (58 ± 1 years), and 36 young men (27 ± 1 years) were studied. Heart rate, BP, and muscle sympathetic nerve activity (MSNA) were monitored. Sympathetic BRS was analyzed using the slope of the MSNA-diastolic blood pressure (DBP) relationship and cardiac BRS was analyzed using the R–R interval-systolic blood pressure (SBP) relationship. Young women and men had similar mean arterial pressures (MAP, 91 ± 1 vs. 90 ± 1 mmHg), cardiac BRS (19 ± 1 vs. 21 ± 2 ms/mmHg), and sympathetic BRS (−6 ± 1 vs. −7 ± 1 AU/beat/mmHg), respectively. Older women had higher MAP (104 ± 4 mmHg, p < 0.05) and lower cardiac BRS (7 ± 1 ms/mmHg, p < 0.05), but similar sympathetic BRS (−8 ± 1 AU/beat/mmHg). There was no association between BP transients with either cardiac or sympathetic BRS in young women. In the older women, the drop in SBP, DBP, and MAP were associated with cardiac BRS (r = 0.60, r = 0.59, and r = 0.70, respectively; p < 0.05), but not sympathetic BRS. The decrease in SBP was positively related to cardiac BRS in young men (r = 0.41; p < 0.05). However, there was no relationship between the decrease in BP and sympathetic BRS. This indicates that older women and young men with low cardiac BRS have larger transients in BP during nitroprusside. This suggests a more prominent role for cardiac (as opposed to sympathetic) BRS in responding to acute BP changes in young men and older women. The fact that these relationships do not exist in young women suggest that the female sex hormones influence baroreflex responses. Frontiers Research Foundation 2012-06-07 /pmc/articles/PMC3369369/ /pubmed/22701103 http://dx.doi.org/10.3389/fphys.2012.00187 Text en Copyright © 2012 Barnes, Matzek, Charkoudian, Joyner, Curry and Hart. http://www.frontiersin.org/licenseagreement This is an open-access article distributed under the terms of the Creative Commons Attribution Non Commercial License, which permits non-commercial use, distribution, and reproduction in other forums, provided the original authors and source are credited.
spellingShingle Physiology
Barnes, Jill N.
Matzek, Luke J.
Charkoudian, Nisha
Joyner, Michael J.
Curry, Timothy B.
Hart, Emma C.
Association of Cardiac Baroreflex Sensitivity with Blood Pressure Transients: Influence of Sex and Menopausal Status
title Association of Cardiac Baroreflex Sensitivity with Blood Pressure Transients: Influence of Sex and Menopausal Status
title_full Association of Cardiac Baroreflex Sensitivity with Blood Pressure Transients: Influence of Sex and Menopausal Status
title_fullStr Association of Cardiac Baroreflex Sensitivity with Blood Pressure Transients: Influence of Sex and Menopausal Status
title_full_unstemmed Association of Cardiac Baroreflex Sensitivity with Blood Pressure Transients: Influence of Sex and Menopausal Status
title_short Association of Cardiac Baroreflex Sensitivity with Blood Pressure Transients: Influence of Sex and Menopausal Status
title_sort association of cardiac baroreflex sensitivity with blood pressure transients: influence of sex and menopausal status
topic Physiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3369369/
https://www.ncbi.nlm.nih.gov/pubmed/22701103
http://dx.doi.org/10.3389/fphys.2012.00187
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