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Successful Treatment of Primary Sclerosing Cholangitis with a Steroid and a Probiotic

Primary sclerosing cholangitis (PSC) is a serious disease that not only affects quality of life but can also have a significant effect on patient survival. The treatment for PSC is primarily supportive with the aim of controlling cholestatic symptoms and preventing complications. Ursodeoxycholic aci...

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Autores principales: Shimizu, Masaki, Iwasaki, Hidenori, Mase, Shintaro, Yachie, Akihiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: S. Karger AG 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3369409/
https://www.ncbi.nlm.nih.gov/pubmed/22679413
http://dx.doi.org/10.1159/000338834
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author Shimizu, Masaki
Iwasaki, Hidenori
Mase, Shintaro
Yachie, Akihiro
author_facet Shimizu, Masaki
Iwasaki, Hidenori
Mase, Shintaro
Yachie, Akihiro
author_sort Shimizu, Masaki
collection PubMed
description Primary sclerosing cholangitis (PSC) is a serious disease that not only affects quality of life but can also have a significant effect on patient survival. The treatment for PSC is primarily supportive with the aim of controlling cholestatic symptoms and preventing complications. Ursodeoxycholic acid may induce biochemical improvements in affected patients; however, long-term pediatric studies to determine its possible benefits in young patients are lacking. Thus, the treatment of pediatric PSC remains a significant clinical challenge. We describe a patient with PSC and undetermined colitis who was treated with a combination of a steroid, salazosulfapyridine, and a probiotic. This treatment provided benefits both for PSC and the undetermined colitis. These findings suggest that bacterial flora and gut inflammation are closely associated with the pathogenesis of inflammatory bowel disease-related PSC. Suppression of bowel inflammation and maintenance of bacterial homeostasis may be important for treating PSC.
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spelling pubmed-33694092012-06-07 Successful Treatment of Primary Sclerosing Cholangitis with a Steroid and a Probiotic Shimizu, Masaki Iwasaki, Hidenori Mase, Shintaro Yachie, Akihiro Case Rep Gastroenterol Published: May, 2012 Primary sclerosing cholangitis (PSC) is a serious disease that not only affects quality of life but can also have a significant effect on patient survival. The treatment for PSC is primarily supportive with the aim of controlling cholestatic symptoms and preventing complications. Ursodeoxycholic acid may induce biochemical improvements in affected patients; however, long-term pediatric studies to determine its possible benefits in young patients are lacking. Thus, the treatment of pediatric PSC remains a significant clinical challenge. We describe a patient with PSC and undetermined colitis who was treated with a combination of a steroid, salazosulfapyridine, and a probiotic. This treatment provided benefits both for PSC and the undetermined colitis. These findings suggest that bacterial flora and gut inflammation are closely associated with the pathogenesis of inflammatory bowel disease-related PSC. Suppression of bowel inflammation and maintenance of bacterial homeostasis may be important for treating PSC. S. Karger AG 2012-05-08 /pmc/articles/PMC3369409/ /pubmed/22679413 http://dx.doi.org/10.1159/000338834 Text en Copyright © 2012 by S. Karger AG, Basel http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Noncommercial-No-Derivative-Works License (http://creativecommons.org/licenses/by-nc-nd/3.0/). Users may download, print and share this work on the Internet for noncommercial purposes only, provided the original work is properly cited, and a link to the original work on http://www.karger.com and the terms of this license are included in any shared versions.
spellingShingle Published: May, 2012
Shimizu, Masaki
Iwasaki, Hidenori
Mase, Shintaro
Yachie, Akihiro
Successful Treatment of Primary Sclerosing Cholangitis with a Steroid and a Probiotic
title Successful Treatment of Primary Sclerosing Cholangitis with a Steroid and a Probiotic
title_full Successful Treatment of Primary Sclerosing Cholangitis with a Steroid and a Probiotic
title_fullStr Successful Treatment of Primary Sclerosing Cholangitis with a Steroid and a Probiotic
title_full_unstemmed Successful Treatment of Primary Sclerosing Cholangitis with a Steroid and a Probiotic
title_short Successful Treatment of Primary Sclerosing Cholangitis with a Steroid and a Probiotic
title_sort successful treatment of primary sclerosing cholangitis with a steroid and a probiotic
topic Published: May, 2012
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3369409/
https://www.ncbi.nlm.nih.gov/pubmed/22679413
http://dx.doi.org/10.1159/000338834
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