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Ischemia/Reperfusion Injury in Liver Surgery and Transplantation: Pathophysiology
Liver ischemia/reperfusion (IR) injury is caused by a heavily toothed network of interactions of cells of the immune system, cytokine production, and reduced microcirculatory blood flow in the liver. These complex networks are further elaborated by multiple intracellular pathways activated by cytoki...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3369424/ https://www.ncbi.nlm.nih.gov/pubmed/22693364 http://dx.doi.org/10.1155/2012/176723 |
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author | Weigand, Kilian Brost, Sylvia Steinebrunner, Niels Büchler, Markus Schemmer, Peter Müller, Martina |
author_facet | Weigand, Kilian Brost, Sylvia Steinebrunner, Niels Büchler, Markus Schemmer, Peter Müller, Martina |
author_sort | Weigand, Kilian |
collection | PubMed |
description | Liver ischemia/reperfusion (IR) injury is caused by a heavily toothed network of interactions of cells of the immune system, cytokine production, and reduced microcirculatory blood flow in the liver. These complex networks are further elaborated by multiple intracellular pathways activated by cytokines, chemokines, and danger-associated molecular patterns. Furthermore, intracellular ionic disturbances and especially mitochondrial disorders play an important role leading to apoptosis and necrosis of hepatocytes in IR injury. Overall, enhanced production of reactive oxygen species, found very early in IR injury, plays an important role in liver tissue damage at several points within these complex networks. Many contributors to IR injury are only incompletely understood so far. This paper tempts to give an overview of the different mechanisms involved in the formation of IR injury. Only by further elucidation of these complex mechanisms IR injury can be understood and possible therapeutic strategies can be improved or be developed. |
format | Online Article Text |
id | pubmed-3369424 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-33694242012-06-12 Ischemia/Reperfusion Injury in Liver Surgery and Transplantation: Pathophysiology Weigand, Kilian Brost, Sylvia Steinebrunner, Niels Büchler, Markus Schemmer, Peter Müller, Martina HPB Surg Review Article Liver ischemia/reperfusion (IR) injury is caused by a heavily toothed network of interactions of cells of the immune system, cytokine production, and reduced microcirculatory blood flow in the liver. These complex networks are further elaborated by multiple intracellular pathways activated by cytokines, chemokines, and danger-associated molecular patterns. Furthermore, intracellular ionic disturbances and especially mitochondrial disorders play an important role leading to apoptosis and necrosis of hepatocytes in IR injury. Overall, enhanced production of reactive oxygen species, found very early in IR injury, plays an important role in liver tissue damage at several points within these complex networks. Many contributors to IR injury are only incompletely understood so far. This paper tempts to give an overview of the different mechanisms involved in the formation of IR injury. Only by further elucidation of these complex mechanisms IR injury can be understood and possible therapeutic strategies can be improved or be developed. Hindawi Publishing Corporation 2012 2012-05-30 /pmc/articles/PMC3369424/ /pubmed/22693364 http://dx.doi.org/10.1155/2012/176723 Text en Copyright © 2012 Kilian Weigand et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Weigand, Kilian Brost, Sylvia Steinebrunner, Niels Büchler, Markus Schemmer, Peter Müller, Martina Ischemia/Reperfusion Injury in Liver Surgery and Transplantation: Pathophysiology |
title | Ischemia/Reperfusion Injury in Liver Surgery and Transplantation: Pathophysiology |
title_full | Ischemia/Reperfusion Injury in Liver Surgery and Transplantation: Pathophysiology |
title_fullStr | Ischemia/Reperfusion Injury in Liver Surgery and Transplantation: Pathophysiology |
title_full_unstemmed | Ischemia/Reperfusion Injury in Liver Surgery and Transplantation: Pathophysiology |
title_short | Ischemia/Reperfusion Injury in Liver Surgery and Transplantation: Pathophysiology |
title_sort | ischemia/reperfusion injury in liver surgery and transplantation: pathophysiology |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3369424/ https://www.ncbi.nlm.nih.gov/pubmed/22693364 http://dx.doi.org/10.1155/2012/176723 |
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