Cargando…

Endothelial Dysfunction and Increased Carotid Intima-Media Thickness in the Patients with Slow Coronary Flow

Flow mediated brachial dilatation (FMD) and carotid intima-media thickness (IMT) have been a surrogate for early atherosclerosis. Slow coronary flow in a normal coronary angiogram is not a rare condition, but its pathogenesis remains unclear. A total of 85 patients with angina were evaluated of thei...

Descripción completa

Detalles Bibliográficos
Autores principales: Yoon, Hyun Ju, Jeong, Myung Ho, Cho, Sook Hee, Kim, Kye Hun, Lee, Min Goo, Park, Keun Ho, Sim, Doo Sun, Yoon, Nam Sik, Hong, Young Joon, Kim, Ju Han, Ahn, Youngkeun, Cho, Jeong Gwan, Park, Jong Chun, Kang, Jung Chaee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Academy of Medical Sciences 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3369446/
https://www.ncbi.nlm.nih.gov/pubmed/22690091
http://dx.doi.org/10.3346/jkms.2012.27.6.614
_version_ 1782235058486116352
author Yoon, Hyun Ju
Jeong, Myung Ho
Cho, Sook Hee
Kim, Kye Hun
Lee, Min Goo
Park, Keun Ho
Sim, Doo Sun
Yoon, Nam Sik
Hong, Young Joon
Kim, Ju Han
Ahn, Youngkeun
Cho, Jeong Gwan
Park, Jong Chun
Kang, Jung Chaee
author_facet Yoon, Hyun Ju
Jeong, Myung Ho
Cho, Sook Hee
Kim, Kye Hun
Lee, Min Goo
Park, Keun Ho
Sim, Doo Sun
Yoon, Nam Sik
Hong, Young Joon
Kim, Ju Han
Ahn, Youngkeun
Cho, Jeong Gwan
Park, Jong Chun
Kang, Jung Chaee
author_sort Yoon, Hyun Ju
collection PubMed
description Flow mediated brachial dilatation (FMD) and carotid intima-media thickness (IMT) have been a surrogate for early atherosclerosis. Slow coronary flow in a normal coronary angiogram is not a rare condition, but its pathogenesis remains unclear. A total of 85 patients with angina were evaluated of their brachial artery FMD, carotid IMT and conventional coronary angiography. Coronary flow was quantified using the corrected thrombosis in myocardial infarction (TIMI) frame count method. Group I was a control with normal coronary angiography (n = 41, 56.1 ± 8.0 yr) and group II was no significant coronary stenosis with slow flow (n = 44, 56.3 ± 10.0 yr). Diabetes was rare but dyslipidemia and family history were frequent in group II. Heart rate was higher in group II than in group I. White blood cells, especially monocytes and homocysteine were higher in group II. The FMD was significantly lower in group II than in group I. Elevated heart rate, dyslipidemia and low FMD were independently related with slow coronary flow in regression analysis. Therefore, endothelial dysfunction may be an earlier vascular phenomenon than increased carotid IMT in the patients with slow coronary flow.
format Online
Article
Text
id pubmed-3369446
institution National Center for Biotechnology Information
language English
publishDate 2012
publisher The Korean Academy of Medical Sciences
record_format MEDLINE/PubMed
spelling pubmed-33694462012-06-11 Endothelial Dysfunction and Increased Carotid Intima-Media Thickness in the Patients with Slow Coronary Flow Yoon, Hyun Ju Jeong, Myung Ho Cho, Sook Hee Kim, Kye Hun Lee, Min Goo Park, Keun Ho Sim, Doo Sun Yoon, Nam Sik Hong, Young Joon Kim, Ju Han Ahn, Youngkeun Cho, Jeong Gwan Park, Jong Chun Kang, Jung Chaee J Korean Med Sci Original Article Flow mediated brachial dilatation (FMD) and carotid intima-media thickness (IMT) have been a surrogate for early atherosclerosis. Slow coronary flow in a normal coronary angiogram is not a rare condition, but its pathogenesis remains unclear. A total of 85 patients with angina were evaluated of their brachial artery FMD, carotid IMT and conventional coronary angiography. Coronary flow was quantified using the corrected thrombosis in myocardial infarction (TIMI) frame count method. Group I was a control with normal coronary angiography (n = 41, 56.1 ± 8.0 yr) and group II was no significant coronary stenosis with slow flow (n = 44, 56.3 ± 10.0 yr). Diabetes was rare but dyslipidemia and family history were frequent in group II. Heart rate was higher in group II than in group I. White blood cells, especially monocytes and homocysteine were higher in group II. The FMD was significantly lower in group II than in group I. Elevated heart rate, dyslipidemia and low FMD were independently related with slow coronary flow in regression analysis. Therefore, endothelial dysfunction may be an earlier vascular phenomenon than increased carotid IMT in the patients with slow coronary flow. The Korean Academy of Medical Sciences 2012-06 2012-05-26 /pmc/articles/PMC3369446/ /pubmed/22690091 http://dx.doi.org/10.3346/jkms.2012.27.6.614 Text en © 2012 The Korean Academy of Medical Sciences. http://creativecommons.org/licenses/by-nc/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Yoon, Hyun Ju
Jeong, Myung Ho
Cho, Sook Hee
Kim, Kye Hun
Lee, Min Goo
Park, Keun Ho
Sim, Doo Sun
Yoon, Nam Sik
Hong, Young Joon
Kim, Ju Han
Ahn, Youngkeun
Cho, Jeong Gwan
Park, Jong Chun
Kang, Jung Chaee
Endothelial Dysfunction and Increased Carotid Intima-Media Thickness in the Patients with Slow Coronary Flow
title Endothelial Dysfunction and Increased Carotid Intima-Media Thickness in the Patients with Slow Coronary Flow
title_full Endothelial Dysfunction and Increased Carotid Intima-Media Thickness in the Patients with Slow Coronary Flow
title_fullStr Endothelial Dysfunction and Increased Carotid Intima-Media Thickness in the Patients with Slow Coronary Flow
title_full_unstemmed Endothelial Dysfunction and Increased Carotid Intima-Media Thickness in the Patients with Slow Coronary Flow
title_short Endothelial Dysfunction and Increased Carotid Intima-Media Thickness in the Patients with Slow Coronary Flow
title_sort endothelial dysfunction and increased carotid intima-media thickness in the patients with slow coronary flow
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3369446/
https://www.ncbi.nlm.nih.gov/pubmed/22690091
http://dx.doi.org/10.3346/jkms.2012.27.6.614
work_keys_str_mv AT yoonhyunju endothelialdysfunctionandincreasedcarotidintimamediathicknessinthepatientswithslowcoronaryflow
AT jeongmyungho endothelialdysfunctionandincreasedcarotidintimamediathicknessinthepatientswithslowcoronaryflow
AT chosookhee endothelialdysfunctionandincreasedcarotidintimamediathicknessinthepatientswithslowcoronaryflow
AT kimkyehun endothelialdysfunctionandincreasedcarotidintimamediathicknessinthepatientswithslowcoronaryflow
AT leemingoo endothelialdysfunctionandincreasedcarotidintimamediathicknessinthepatientswithslowcoronaryflow
AT parkkeunho endothelialdysfunctionandincreasedcarotidintimamediathicknessinthepatientswithslowcoronaryflow
AT simdoosun endothelialdysfunctionandincreasedcarotidintimamediathicknessinthepatientswithslowcoronaryflow
AT yoonnamsik endothelialdysfunctionandincreasedcarotidintimamediathicknessinthepatientswithslowcoronaryflow
AT hongyoungjoon endothelialdysfunctionandincreasedcarotidintimamediathicknessinthepatientswithslowcoronaryflow
AT kimjuhan endothelialdysfunctionandincreasedcarotidintimamediathicknessinthepatientswithslowcoronaryflow
AT ahnyoungkeun endothelialdysfunctionandincreasedcarotidintimamediathicknessinthepatientswithslowcoronaryflow
AT chojeonggwan endothelialdysfunctionandincreasedcarotidintimamediathicknessinthepatientswithslowcoronaryflow
AT parkjongchun endothelialdysfunctionandincreasedcarotidintimamediathicknessinthepatientswithslowcoronaryflow
AT kangjungchaee endothelialdysfunctionandincreasedcarotidintimamediathicknessinthepatientswithslowcoronaryflow