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Pentosan polysulfate increases affinity between ADAMTS-5 and TIMP-3 through formation of an electrostatically driven trimolecular complex

The semi-synthetic sulfated polysaccharide PPS (pentosan polysulfate) increases affinity between the aggrecan-degrading ADAMTSs (adamalysins with thrombospondin motifs) and their endogenous inhibitor, TIMP (tissue inhibitor of metalloproteinases)-3. In the present study we demonstrate that PPS media...

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Detalles Bibliográficos
Autores principales:	Troeberg, Linda, Mulloy, Barbara, Ghosh, Peter, Lee, Meng-Huee, Murphy, Gillian, Nagase, Hideaki
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Portland Press Ltd. 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3369482/ https://www.ncbi.nlm.nih.gov/pubmed/22299597 http://dx.doi.org/10.1042/BJ20112159

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