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The Importance of Definitive Diagnosis in Chronic Schistosomiasis, with Reference to Schistosoma haematobium

Schistosomes are long-lived parasites, hence schistosomiasis is a chronic disease with severe long-term implications. However, definitive diagnosis of active infection has been difficult because demonstration of infection has depended on detecting parasite eggs in urine and/or stool. In the case of...

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Detalles Bibliográficos
Autor principal: Shiff, Clive
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3369489/
https://www.ncbi.nlm.nih.gov/pubmed/22701165
http://dx.doi.org/10.1155/2012/761269
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author Shiff, Clive
author_facet Shiff, Clive
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description Schistosomes are long-lived parasites, hence schistosomiasis is a chronic disease with severe long-term implications. However, definitive diagnosis of active infection has been difficult because demonstration of infection has depended on detecting parasite eggs in urine and/or stool. In the case of Schistosoma haematobium which parasitizes the urinogenital system, this method has low sensitivity in adults. Detection of parasite-specific DNA in urine has been demonstrated and this has similar specificity but improved sensitivity. The implications of this new procedure and the impact on diagnosis are discussed.
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spelling pubmed-33694892012-06-13 The Importance of Definitive Diagnosis in Chronic Schistosomiasis, with Reference to Schistosoma haematobium Shiff, Clive J Parasitol Res Review Article Schistosomes are long-lived parasites, hence schistosomiasis is a chronic disease with severe long-term implications. However, definitive diagnosis of active infection has been difficult because demonstration of infection has depended on detecting parasite eggs in urine and/or stool. In the case of Schistosoma haematobium which parasitizes the urinogenital system, this method has low sensitivity in adults. Detection of parasite-specific DNA in urine has been demonstrated and this has similar specificity but improved sensitivity. The implications of this new procedure and the impact on diagnosis are discussed. Hindawi Publishing Corporation 2012 2012-05-30 /pmc/articles/PMC3369489/ /pubmed/22701165 http://dx.doi.org/10.1155/2012/761269 Text en Copyright © 2012 Clive Shiff. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Shiff, Clive
The Importance of Definitive Diagnosis in Chronic Schistosomiasis, with Reference to Schistosoma haematobium
title The Importance of Definitive Diagnosis in Chronic Schistosomiasis, with Reference to Schistosoma haematobium
title_full The Importance of Definitive Diagnosis in Chronic Schistosomiasis, with Reference to Schistosoma haematobium
title_fullStr The Importance of Definitive Diagnosis in Chronic Schistosomiasis, with Reference to Schistosoma haematobium
title_full_unstemmed The Importance of Definitive Diagnosis in Chronic Schistosomiasis, with Reference to Schistosoma haematobium
title_short The Importance of Definitive Diagnosis in Chronic Schistosomiasis, with Reference to Schistosoma haematobium
title_sort importance of definitive diagnosis in chronic schistosomiasis, with reference to schistosoma haematobium
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3369489/
https://www.ncbi.nlm.nih.gov/pubmed/22701165
http://dx.doi.org/10.1155/2012/761269
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