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Epidemiology of Burkholderia cepacia Complex in Patients with Cystic Fibrosis, Canada
The Burkholderia cepacia complex is an important group of pathogens in patients with cystic fibrosis (CF). Although evidence for patient-to-patient spread is clear, microbial factors facilitating transmission are poorly understood. To identify microbial clones with enhanced transmissibility, we eval...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Centers for Disease Control and Prevention
2002
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3369581/ https://www.ncbi.nlm.nih.gov/pubmed/11897071 http://dx.doi.org/10.3201/eid0802.010163 |
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author | Speert, David P. Henry, Deborah Vandamme, Peter Corey, Mary Mahenthiralingam, Eshwar |
author_facet | Speert, David P. Henry, Deborah Vandamme, Peter Corey, Mary Mahenthiralingam, Eshwar |
author_sort | Speert, David P. |
collection | PubMed |
description | The Burkholderia cepacia complex is an important group of pathogens in patients with cystic fibrosis (CF). Although evidence for patient-to-patient spread is clear, microbial factors facilitating transmission are poorly understood. To identify microbial clones with enhanced transmissibility, we evaluated B. cepacia complex isolates from patients with CF from throughout Canada. A total of 905 isolates from the B. cepacia complex were recovered from 447 patients in 8 of the 10 provinces; 369 (83%) of these patients had genomovar III and 43 (9.6%) had B. multivorans (genomovar II). Infection prevalence differed substantially by region (22% of patients in Ontario vs. 5% in Quebec). Results of typing by random amplified polymorphic DNA analysis or pulsed-field gel electrophoresis indicated that strains of B. cepacia complex from genomovar III are the most potentially transmissible and that the B. cepacia epidemic strain marker is a robust marker for transmissibility. |
format | Online Article Text |
id | pubmed-3369581 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2002 |
publisher | Centers for Disease Control and Prevention |
record_format | MEDLINE/PubMed |
spelling | pubmed-33695812012-06-21 Epidemiology of Burkholderia cepacia Complex in Patients with Cystic Fibrosis, Canada Speert, David P. Henry, Deborah Vandamme, Peter Corey, Mary Mahenthiralingam, Eshwar Emerg Infect Dis Research The Burkholderia cepacia complex is an important group of pathogens in patients with cystic fibrosis (CF). Although evidence for patient-to-patient spread is clear, microbial factors facilitating transmission are poorly understood. To identify microbial clones with enhanced transmissibility, we evaluated B. cepacia complex isolates from patients with CF from throughout Canada. A total of 905 isolates from the B. cepacia complex were recovered from 447 patients in 8 of the 10 provinces; 369 (83%) of these patients had genomovar III and 43 (9.6%) had B. multivorans (genomovar II). Infection prevalence differed substantially by region (22% of patients in Ontario vs. 5% in Quebec). Results of typing by random amplified polymorphic DNA analysis or pulsed-field gel electrophoresis indicated that strains of B. cepacia complex from genomovar III are the most potentially transmissible and that the B. cepacia epidemic strain marker is a robust marker for transmissibility. Centers for Disease Control and Prevention 2002-02 /pmc/articles/PMC3369581/ /pubmed/11897071 http://dx.doi.org/10.3201/eid0802.010163 Text en https://creativecommons.org/licenses/by/4.0/This is a publication of the U.S. Government. This publication is in the public domain and is therefore without copyright. All text from this work may be reprinted freely. Use of these materials should be properly cited. |
spellingShingle | Research Speert, David P. Henry, Deborah Vandamme, Peter Corey, Mary Mahenthiralingam, Eshwar Epidemiology of Burkholderia cepacia Complex in Patients with Cystic Fibrosis, Canada |
title | Epidemiology of Burkholderia cepacia Complex in Patients with Cystic Fibrosis, Canada |
title_full | Epidemiology of Burkholderia cepacia Complex in Patients with Cystic Fibrosis, Canada |
title_fullStr | Epidemiology of Burkholderia cepacia Complex in Patients with Cystic Fibrosis, Canada |
title_full_unstemmed | Epidemiology of Burkholderia cepacia Complex in Patients with Cystic Fibrosis, Canada |
title_short | Epidemiology of Burkholderia cepacia Complex in Patients with Cystic Fibrosis, Canada |
title_sort | epidemiology of burkholderia cepacia complex in patients with cystic fibrosis, canada |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3369581/ https://www.ncbi.nlm.nih.gov/pubmed/11897071 http://dx.doi.org/10.3201/eid0802.010163 |
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