Design Novel Dual Agonists for Treating Type-2 Diabetes by Targeting Peroxisome Proliferator-Activated Receptors with Core Hopping Approach

Owing to their unique functions in regulating glucose, lipid and cholesterol metabolism, PPARs (peroxisome proliferator-activated receptors) have drawn special attention for developing drugs to treat type-2 diabetes. By combining the lipid benefit of PPAR-alpha agonists (such as fibrates) with the g...

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Detalles Bibliográficos
Autores principales: Ma, Ying, Wang, Shu-Qing, Xu, Wei-Ren, Wang, Run-Ling, Chou, Kuo-Chen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3369836/
https://www.ncbi.nlm.nih.gov/pubmed/22685582
http://dx.doi.org/10.1371/journal.pone.0038546

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3369836/
https://www.ncbi.nlm.nih.gov/pubmed/22685582
http://dx.doi.org/10.1371/journal.pone.0038546

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