Cargando…

saeRS and sarA Act Synergistically to Repress Protease Production and Promote Biofilm Formation in Staphylococcus aureus

Mutation of the staphylococcal accessory regulator (sarA) limits biofilm formation in diverse strains of Staphylococcus aureus, but there are exceptions. One of these is the commonly studied strain Newman. This strain has two defects of potential relevance, the first being mutations that preclude an...

Descripción completa

Detalles Bibliográficos
Autores principales:	Mrak, Lara N., Zielinska, Agnieszka K., Beenken, Karen E., Mrak, Ian N., Atwood, Danielle N., Griffin, Linda M., Lee, Chia Y., Smeltzer, Mark S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3369899/ https://www.ncbi.nlm.nih.gov/pubmed/22685571 http://dx.doi.org/10.1371/journal.pone.0038453

Ejemplares similares

SaeRS-Dependent Inhibition of Biofilm Formation in Staphylococcus aureus Newman
por: Cue, David, et al.
Publicado: (2015)

Epistatic Relationships between sarA and agr in Staphylococcus aureus Biofilm Formation
por: Beenken, Karen E., et al.
Publicado: (2010)

Exploiting Correlations between Protein Abundance and the Functional Status of saeRS and sarA To Identify Virulence Factors of Potential Importance in the Pathogenesis of Staphylococcus aureus Osteomyelitis
por: Ramirez, Aura M., et al.
Publicado: (2019)

The SaeRS Two-Component System of Staphylococcus aureus
por: Liu, Qian, et al.
Publicado: (2016)

Subinhibitory Concentrations of Fusidic Acid May Reduce the Virulence of S. aureus by Down-Regulating sarA and saeRS to Reduce Biofilm Formation and α-Toxin Expression
por: Liu, Li, et al.
Publicado: (2020)

Impact of individual extracellular proteases on Staphylococcus aureus biofilm formation in diverse clinical isolates and their isogenic sarA mutants
por: Loughran, Allister J, et al.
Publicado: (2014)

Factors Contributing to the Biofilm-Deficient Phenotype of Staphylococcus aureus sarA Mutants
por: Tsang, Laura H., et al.
Publicado: (2008)

Role of the SaeRS two-component regulatory system in Staphylococcus epidermidis autolysis and biofilm formation
por: Lou, Qiang, et al.
Publicado: (2011)

NWMN2330 May Be Associated with the Virulence of Staphylococcus aureus by Increasing the Expression of hla and saeRS
por: Liu, Li, et al.
Publicado: (2022)

Subinhibitory concentrations of resveratrol reduce alpha-hemolysin production in Staphylococcus aureus isolates by downregulating saeRS
por: Duan, Jingjing, et al.
Publicado: (2018)

Commensal Staphylococcus epidermidis Defends against Staphylococcus aureus through SaeRS Two-Component System
por: Nurxat, Nadira, et al.
Publicado: (2023)

Aspartic Acid Residue 51 of SaeR Is Essential for Staphylococcus aureus Virulence
por: Nygaard, Tyler K., et al.
Publicado: (2018)

Staphylococcus aureus sarA Regulates Inflammation and Colonization during Central Nervous System Biofilm Formation
por: Snowden, Jessica N., et al.
Publicado: (2013)

Characterization and virulence of Streptococcus agalactiae deficient in SaeRS of the two-component system
por: Li, Shiyu, et al.
Publicado: (2023)

Calprotectin Increases the Activity of the SaeRS Two Component System and Murine Mortality during Staphylococcus aureus Infections
por: Cho, Hoonsik, et al.
Publicado: (2015)

The SaeRS Two-Component System Controls Survival of Staphylococcus aureus in Human Blood through Regulation of Coagulase
por: Guo, Haiyong, et al.
Publicado: (2017)

Molybdopterin biosynthesis pathway contributes to the regulation of SaeRS two-component system by ClpP in Staphylococcus aureus
por: Zhao, Na, et al.
Publicado: (2022)

The Small Protein ScrA Influences Staphylococcus aureus Virulence-Related Processes via the SaeRS System
por: Wittekind, Marcus A., et al.
Publicado: (2023)

SaeR as a novel target for antivirulence therapy against Staphylococcus aureus
por: Gao, Peng, et al.
Publicado: (2023)

Contribution of Coagulase and Its Regulator SaeRS to Lethality of CA-MRSA 923 Bacteremia
por: Liu, Ying, et al.
Publicado: (2021)

Sub-Inhibitory Concentrations of Mupirocin Strongly Inhibit Alpha-Toxin Production in High-Level Mupirocin-Resistant MRSA by Down-Regulating agr, saeRS, and sarA
por: Jin, Ye, et al.
Publicado: (2018)

Role of Fatty Acid Kinase in Cellular Lipid Homeostasis and SaeRS-Dependent Virulence Factor Expression in Staphylococcus aureus
por: Ericson, Megan E., et al.
Publicado: (2017)

The novel protein ScrA acts through the SaeRS two‐component system to regulate virulence gene expression in Staphylococcus aureus
por: Wittekind, Marcus A., et al.
Publicado: (2022)

Importance of the Global Regulators Agr and SaeRS in the Pathogenesis of CA-MRSA USA300 Infection
por: Montgomery, Christopher P., et al.
Publicado: (2010)

The major role of sarA in limiting Staphylococcus aureus extracellular protease production in vitro is correlated with decreased virulence in diverse clinical isolates in osteomyelitis
por: Campbell, Mara J., et al.
Publicado: (2023)

Repurposed Fenoprofen Targeting SaeR Attenuates Staphylococcus aureus Virulence in Implant-Associated Infections
por: Jiang, Feng, et al.
Publicado: (2023)

A Critical Role for HlgA in Staphylococcus aureus Pathogenesis Revealed by A Switch in the SaeRS Two-Component Regulatory System
por: Venkatasubramaniam, Arundhathi, et al.
Publicado: (2018)

Two-Component Signal Transduction System SaeRS Positively Regulates Staphylococcus epidermidis Glucose Metabolism
por: Lou, Qiang, et al.
Publicado: (2014)

SarA plays a predominant role in controlling the production of extracellular proteases in the diverse clinical isolates of Staphylococcus aureus LAC and UAMS-1
por: Ramirez, Aura M., et al.
Publicado: (2020)

The Accessory Gene saeP of the SaeR/S Two-Component Gene Regulatory System Impacts Staphylococcus aureus Virulence During Neutrophil Interaction
por: Collins, Madison M., et al.
Publicado: (2020)

Label-Free Proteomic Approach to Characterize Protease-Dependent and -Independent Effects of sarA Inactivation on the Staphylococcus aureus Exoproteome
por: Byrum, Stephanie D., et al.
Publicado: (2018)

The SaeR/S Gene Regulatory System Induces a Pro-Inflammatory Cytokine Response during Staphylococcus aureus Infection
por: Watkins, Robert L., et al.
Publicado: (2011)

The Impacts of msaABCR on sarA-Associated Phenotypes Are Different in Divergent Clinical Isolates of Staphylococcus aureus
por: Rom, Joseph S., et al.
Publicado: (2020)

Inhibition of Rho Activity Increases Expression of SaeRS-Dependent Virulence Factor Genes in Staphylococcus aureus, Showing a Link between Transcription Termination, Antibiotic Action, and Virulence
por: Nagel, Anna, et al.
Publicado: (2018)

The Staphylococcal Accessory Regulator, SarA, is an RNA-Binding Protein that Modulates the mRNA Turnover Properties of Late-Exponential and Stationary Phase Staphylococcus aureus Cells
por: Morrison, John M., et al.
Publicado: (2012)

Stochastic Expression of Sae-Dependent Virulence Genes during Staphylococcus aureus Biofilm Development Is Dependent on SaeS
por: DelMain, Elizabeth A., et al.
Publicado: (2020)

Comparative impact of diverse regulatory loci on Staphylococcus aureus biofilm formation
por: Atwood, Danielle N, et al.
Publicado: (2015)

Impact of Staphylococcus aureus regulatory mutations that modulate biofilm formation in the USA300 strain LAC on virulence in a murine bacteremia model
por: Rom, Joseph S., et al.
Publicado: (2017)

SDS Interferes with SaeS Signaling of Staphylococcus aureus Independently of SaePQ
por: Makgotlho, Phuti E., et al.
Publicado: (2013)

Synergistic Photothermal and Antibiotic Killing of Biofilm-Associated Staphylococcus aureus Using Targeted Antibiotic-Loaded Gold Nanoconstructs
por: Meeker, Daniel G., et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_p8vlb7eutteb8s2re1r5v4hiht