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Structural and Dynamic Requirements for Optimal Activity of the Essential Bacterial Enzyme Dihydrodipicolinate Synthase

Dihydrodipicolinate synthase (DHDPS) is an essential enzyme involved in the lysine biosynthesis pathway. DHDPS from E. coli is a homotetramer consisting of a ‘dimer of dimers’, with the catalytic residues found at the tight-dimer interface. Crystallographic and biophysical evidence suggest that the...

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Detalles Bibliográficos
Autores principales:	Reboul, C. F., Porebski, B. T., Griffin, M. D. W., Dobson, R. C. J., Perugini, M. A., Gerrard, J. A., Buckle, A. M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3369909/ https://www.ncbi.nlm.nih.gov/pubmed/22685390 http://dx.doi.org/10.1371/journal.pcbi.1002537

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