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Systematic Single-Cell Analysis of Pichia pastoris Reveals Secretory Capacity Limits Productivity

Biopharmaceuticals represent the fastest growing sector of the global pharmaceutical industry. Cost-efficient production of these biologic drugs requires a robust host organism for generating high titers of protein during fermentation. Understanding key cellular processes that limit protein producti...

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Detalles Bibliográficos
Autores principales:	Love, Kerry Routenberg, Politano, Timothy J., Panagiotou, Vasiliki, Jiang, Bo, Stadheim, Terrance A., Love, J. Christopher
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3369916/ https://www.ncbi.nlm.nih.gov/pubmed/22685548 http://dx.doi.org/10.1371/journal.pone.0037915

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