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Expression in Drosophila of Tandem Amyloid β Peptides Provides Insights into Links between Aggregation and Neurotoxicity

The generation and subsequent aggregation of amyloid β (Aβ) peptides play a crucial initiating role in the pathogenesis of Alzheimer disease (AD). The two main isoforms of these peptides have 40 (Aβ(40)) or 42 residues (Aβ(42)), the latter having a higher propensity to aggregate in vitro and being t...

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Detalles Bibliográficos
Autores principales:	Speretta, Elena, Jahn, Thomas R., Tartaglia, Gian Gaetano, Favrin, Giorgio, Barros, Teresa P., Imarisio, Sara, Lomas, David A., Luheshi, Leila M., Crowther, Damian C., Dobson, Christopher M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2012
Materias:	Molecular Bases of Disease
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3370257/ https://www.ncbi.nlm.nih.gov/pubmed/22461632 http://dx.doi.org/10.1074/jbc.M112.350124

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