Increased myofilament Ca(2+) sensitivity and diastolic dysfunction as early consequences of Mybpc3 mutation in heterozygous knock-in mice

Hypertrophic cardiomyopathy (HCM) is frequently caused by mutations in MYBPC3 encoding cardiac myosin-binding protein C (cMyBP-C). The mechanisms leading from gene mutations to the HCM phenotype remain incompletely understood, partially because current mouse models of HCM do not faithfully reflect t...

Descripción completa

Detalles Bibliográficos
Autores principales: Fraysse, Bodvaël, Weinberger, Florian, Bardswell, Sonya C., Cuello, Friederike, Vignier, Nicolas, Geertz, Birgit, Starbatty, Jutta, Krämer, Elisabeth, Coirault, Catherine, Eschenhagen, Thomas, Kentish, Jonathan C., Avkiran, Metin, Carrier, Lucie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Academic Press 2012
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3370652/
https://www.ncbi.nlm.nih.gov/pubmed/22465693
http://dx.doi.org/10.1016/j.yjmcc.2012.03.009

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3370652/
https://www.ncbi.nlm.nih.gov/pubmed/22465693
http://dx.doi.org/10.1016/j.yjmcc.2012.03.009

Ejemplares similares