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Prognosis of hospitalized patients with 2009 H1N1 influenza in Spain: influence of neuraminidase inhibitors
BACKGROUND: The H1N1 influenza pandemic strain has been associated with a poor prognosis in hospitalized patients. The present report evaluates the factors influencing prognosis. METHODS: A total of 813 patients hospitalized with H1N1 influenza in 36 hospitals (nationwide) in Spain were analysed. De...
Autores principales: | , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3370819/ https://www.ncbi.nlm.nih.gov/pubmed/22467633 http://dx.doi.org/10.1093/jac/dks098 |
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author | Delgado-Rodríguez, Miguel Castilla, Jesús Godoy, Pere Martín, Vicente Soldevila, Nuria Alonso, Jordi Astray, Jenaro Baricot, Maretva Cantón, Rafael Castro, Ady Gónzález-Candelas, Fernando Mayoral, José María Quintana, José María Pumarola, Tomás Tamames, Sonia Sáez, Marc Domínguez, Angela |
author_facet | Delgado-Rodríguez, Miguel Castilla, Jesús Godoy, Pere Martín, Vicente Soldevila, Nuria Alonso, Jordi Astray, Jenaro Baricot, Maretva Cantón, Rafael Castro, Ady Gónzález-Candelas, Fernando Mayoral, José María Quintana, José María Pumarola, Tomás Tamames, Sonia Sáez, Marc Domínguez, Angela |
author_sort | Delgado-Rodríguez, Miguel |
collection | PubMed |
description | BACKGROUND: The H1N1 influenza pandemic strain has been associated with a poor prognosis in hospitalized patients. The present report evaluates the factors influencing prognosis. METHODS: A total of 813 patients hospitalized with H1N1 influenza in 36 hospitals (nationwide) in Spain were analysed. Detailed histories of variables preceding hospital admission were obtained by interview, validating data on medications and vaccine with their attending physicians. Data on treatment and complications during hospital stay were recorded. As definition of poor outcome, the endpoints of death and admission to intensive care were combined; and as a further outcome, length of stay was used. RESULTS: The mean age was 38.5 years (SD 22.8 years). There were 10 deaths and 79 admissions to intensive care (combined, 88). The use of neuraminidase inhibitors was reported by 495 patients (60.9%). The variables significantly associated with a poor outcome were diabetes (OR = 2.21, 95% CI = 1.21–4.02), corticosteroid therapy (OR = 3.37, 95% CI = 1.39–8.20) and use of histamine-2 receptor antagonists (OR = 2.68, 95% CI = 1.14–6.36), while the use of neuraminidase inhibitors (OR = 0.57, 95% CI = 0.34–0.94) was protective. Neuraminidase inhibitors within the first 2 days after the influenza onset reduced hospital stay by a mean of 1.9 days (95% CI = 4.7–6.6). CONCLUSIONS: The use of neuraminidase inhibitors decreases the length of hospital stay and admission to intensive care and/or death. |
format | Online Article Text |
id | pubmed-3370819 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-33708192013-07-01 Prognosis of hospitalized patients with 2009 H1N1 influenza in Spain: influence of neuraminidase inhibitors Delgado-Rodríguez, Miguel Castilla, Jesús Godoy, Pere Martín, Vicente Soldevila, Nuria Alonso, Jordi Astray, Jenaro Baricot, Maretva Cantón, Rafael Castro, Ady Gónzález-Candelas, Fernando Mayoral, José María Quintana, José María Pumarola, Tomás Tamames, Sonia Sáez, Marc Domínguez, Angela J Antimicrob Chemother Original Research BACKGROUND: The H1N1 influenza pandemic strain has been associated with a poor prognosis in hospitalized patients. The present report evaluates the factors influencing prognosis. METHODS: A total of 813 patients hospitalized with H1N1 influenza in 36 hospitals (nationwide) in Spain were analysed. Detailed histories of variables preceding hospital admission were obtained by interview, validating data on medications and vaccine with their attending physicians. Data on treatment and complications during hospital stay were recorded. As definition of poor outcome, the endpoints of death and admission to intensive care were combined; and as a further outcome, length of stay was used. RESULTS: The mean age was 38.5 years (SD 22.8 years). There were 10 deaths and 79 admissions to intensive care (combined, 88). The use of neuraminidase inhibitors was reported by 495 patients (60.9%). The variables significantly associated with a poor outcome were diabetes (OR = 2.21, 95% CI = 1.21–4.02), corticosteroid therapy (OR = 3.37, 95% CI = 1.39–8.20) and use of histamine-2 receptor antagonists (OR = 2.68, 95% CI = 1.14–6.36), while the use of neuraminidase inhibitors (OR = 0.57, 95% CI = 0.34–0.94) was protective. Neuraminidase inhibitors within the first 2 days after the influenza onset reduced hospital stay by a mean of 1.9 days (95% CI = 4.7–6.6). CONCLUSIONS: The use of neuraminidase inhibitors decreases the length of hospital stay and admission to intensive care and/or death. Oxford University Press 2012-07 2012-03-30 /pmc/articles/PMC3370819/ /pubmed/22467633 http://dx.doi.org/10.1093/jac/dks098 Text en © The Author 2012. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com This article is made available via the PMC Open Access Subset for unrestricted re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the COVID-19 pandemic or until permissions are revoked in writing. Upon expiration of these permissions, PMC is granted a perpetual license to make this article available via PMC and Europe PMC, consistent with existing copyright protections. |
spellingShingle | Original Research Delgado-Rodríguez, Miguel Castilla, Jesús Godoy, Pere Martín, Vicente Soldevila, Nuria Alonso, Jordi Astray, Jenaro Baricot, Maretva Cantón, Rafael Castro, Ady Gónzález-Candelas, Fernando Mayoral, José María Quintana, José María Pumarola, Tomás Tamames, Sonia Sáez, Marc Domínguez, Angela Prognosis of hospitalized patients with 2009 H1N1 influenza in Spain: influence of neuraminidase inhibitors |
title | Prognosis of hospitalized patients with 2009 H1N1 influenza in Spain: influence of neuraminidase inhibitors |
title_full | Prognosis of hospitalized patients with 2009 H1N1 influenza in Spain: influence of neuraminidase inhibitors |
title_fullStr | Prognosis of hospitalized patients with 2009 H1N1 influenza in Spain: influence of neuraminidase inhibitors |
title_full_unstemmed | Prognosis of hospitalized patients with 2009 H1N1 influenza in Spain: influence of neuraminidase inhibitors |
title_short | Prognosis of hospitalized patients with 2009 H1N1 influenza in Spain: influence of neuraminidase inhibitors |
title_sort | prognosis of hospitalized patients with 2009 h1n1 influenza in spain: influence of neuraminidase inhibitors |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3370819/ https://www.ncbi.nlm.nih.gov/pubmed/22467633 http://dx.doi.org/10.1093/jac/dks098 |
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