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Microfluidics based phantoms of superficial vascular network

Several new bio-photonic techniques aim to measure flow in the human vasculature non-destructively. Some of these tools, such as laser speckle imaging or Doppler optical coherence tomography, are now reaching the clinical stage. Therefore appropriate calibration and validation techniques dedicated t...

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Detalles Bibliográficos
Autores principales: Luu, Long, Roman, Patrick A., Mathews, Scott A., Ramella-Roman, Jessica C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Optical Society of America 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3370975/
https://www.ncbi.nlm.nih.gov/pubmed/22741081
http://dx.doi.org/10.1364/BOE.3.001350
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author Luu, Long
Roman, Patrick A.
Mathews, Scott A.
Ramella-Roman, Jessica C.
author_facet Luu, Long
Roman, Patrick A.
Mathews, Scott A.
Ramella-Roman, Jessica C.
author_sort Luu, Long
collection PubMed
description Several new bio-photonic techniques aim to measure flow in the human vasculature non-destructively. Some of these tools, such as laser speckle imaging or Doppler optical coherence tomography, are now reaching the clinical stage. Therefore appropriate calibration and validation techniques dedicated to these particular measurements are therefore of paramount importance. In this paper we introduce a fast prototyping technique based on laser micromachining for the fabrication of dynamic flow phantoms. Micro-channels smaller than 20 µm in width can be formed in a variety of materials such as epoxies, plastics, and household tape. Vasculature geometries can be easily and quickly modified to accommodate a particular experimental scenario.
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spelling pubmed-33709752012-06-27 Microfluidics based phantoms of superficial vascular network Luu, Long Roman, Patrick A. Mathews, Scott A. Ramella-Roman, Jessica C. Biomed Opt Express Calibration, Validation and Phantom Studies Several new bio-photonic techniques aim to measure flow in the human vasculature non-destructively. Some of these tools, such as laser speckle imaging or Doppler optical coherence tomography, are now reaching the clinical stage. Therefore appropriate calibration and validation techniques dedicated to these particular measurements are therefore of paramount importance. In this paper we introduce a fast prototyping technique based on laser micromachining for the fabrication of dynamic flow phantoms. Micro-channels smaller than 20 µm in width can be formed in a variety of materials such as epoxies, plastics, and household tape. Vasculature geometries can be easily and quickly modified to accommodate a particular experimental scenario. Optical Society of America 2012-05-14 /pmc/articles/PMC3370975/ /pubmed/22741081 http://dx.doi.org/10.1364/BOE.3.001350 Text en ©2012 Optical Society of America http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 Unported License, which permits download and redistribution, provided that the original work is properly cited. This license restricts the article from being modified or used commercially.
spellingShingle Calibration, Validation and Phantom Studies
Luu, Long
Roman, Patrick A.
Mathews, Scott A.
Ramella-Roman, Jessica C.
Microfluidics based phantoms of superficial vascular network
title Microfluidics based phantoms of superficial vascular network
title_full Microfluidics based phantoms of superficial vascular network
title_fullStr Microfluidics based phantoms of superficial vascular network
title_full_unstemmed Microfluidics based phantoms of superficial vascular network
title_short Microfluidics based phantoms of superficial vascular network
title_sort microfluidics based phantoms of superficial vascular network
topic Calibration, Validation and Phantom Studies
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3370975/
https://www.ncbi.nlm.nih.gov/pubmed/22741081
http://dx.doi.org/10.1364/BOE.3.001350
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