A Randomized, Double Blind, Placebo-Controlled Trial of Pioglitazone in Combination with Riluzole in Amyotrophic Lateral Sclerosis

BACKGROUND: Pioglitazone, an oral anti-diabetic that stimulates the PPAR-gamma transcription factor, increased survival of mice with amyotrophic lateral sclerosis (ALS). METHODS/PRINCIPAL FINDINGS: We performed a phase II, double blind, multicentre, placebo controlled trial of pioglitazone in ALS pa...

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Detalles Bibliográficos
Autores principales: Dupuis, Luc, Dengler, Reinhard, Heneka, Michael T., Meyer, Thomas, Zierz, Stephan, Kassubek, Jan, Fischer, Wilhelm, Steiner, Franziska, Lindauer, Eva, Otto, Markus, Dreyhaupt, Jens, Grehl, Torsten, Hermann, Andreas, Winkler, Andrea S., Bogdahn, Ulrich, Benecke, Reiner, Schrank, Bertold, Wessig, Carsten, Grosskreutz, Julian, Ludolph, Albert C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3371007/
https://www.ncbi.nlm.nih.gov/pubmed/22715372
http://dx.doi.org/10.1371/journal.pone.0037885

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