Cargando…

Ubiquitous Expression of CUG or CAG Trinucleotide Repeat RNA Causes Common Morphological Defects in a Drosophila Model of RNA-Mediated Pathology

Expanded DNA repeat sequences are known to cause over 20 diseases, including Huntington’s disease, several types of spinocerebellar ataxia and myotonic dystrophy type 1 and 2. A shared genetic basis, and overlapping clinical features for some of these diseases, indicate that common pathways may cont...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lawlor, Kynan T., O’Keefe, Louise V., Samaraweera, Saumya E., van Eyk, Clare L., Richards, Robert I.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3371033/ https://www.ncbi.nlm.nih.gov/pubmed/22715390 http://dx.doi.org/10.1371/journal.pone.0038516

Ejemplares similares

Perturbation of the Akt/Gsk3-β signalling pathway is common to Drosophila expressing expanded untranslated CAG, CUG and AUUCU repeat RNAs
por: van Eyk, Clare L., et al.
Publicado: (2011)

On the Applicability of Elastic Network Models for the Study of RNA CUG Trinucleotide Repeat Overexpansion
por: González, Àlex L., et al.
Publicado: (2016)

RNA pathogenesis via Toll-like receptor-activated inflammation in expanded repeat neurodegenerative diseases
por: Richards, Robert I., et al.
Publicado: (2013)

CAG repeats mimic CUG repeats in the misregulation of alternative splicing
por: Mykowska, Agnieszka, et al.
Publicado: (2011)

Atomic resolution structure of CAG RNA repeats: structural insights and implications for the trinucleotide repeat expansion diseases
por: Kiliszek, Agnieszka, et al.
Publicado: (2010)

Molecular insights into the interaction of CAG trinucleotide RNA repeats with nucleolin and its implication in polyglutamine diseases
por: An, Ying, et al.
Publicado: (2022)

Computational Investigation of Bending Properties of RNA AUUCU, CCUG, CAG, and CUG Repeat Expansions Associated With Neuromuscular Disorders
por: Taghavi, Amirhossein, et al.
Publicado: (2022)

Length-dependent energetics of (CTG)(n) and (CAG)(n) trinucleotide repeats
por: Amrane, Samir, et al.
Publicado: (2005)

Instability of (CTG)(n)•(CAG)(n )trinucleotide repeats and DNA synthesis
por: Liu, Guoqi, et al.
Publicado: (2012)

Genome Wide Screening of CAG Trinucleotide Repeat Lengths in Breast Cancer
por: Jarjanazi, Hamdi, et al.
Publicado: (2006)

Repeat Length and RNA Expression Level Are Not Primary Determinants in CUG Expansion Toxicity in Drosophila Models
por: Le Mée, Gwenn, et al.
Publicado: (2008)

Diagrammatic approaches to RNA structures with trinucleotide repeats
por: Mak, Chi H., et al.
Publicado: (2021)

Highly Specific Contractions of a Single CAG/CTG Trinucleotide Repeat by TALEN in Yeast
por: Richard, Guy-Franck, et al.
Publicado: (2014)

Slipped-CAG DNA binding small molecule induces trinucleotide repeat contractions in vivo
por: Nakamori, Masayuki, et al.
Publicado: (2020)

Computational Investigation of RNA CUG Repeats Responsible for Myotonic Dystrophy 1
por: Yildirim, Ilyas, et al.
Publicado: (2015)

Dynamics of strand slippage in DNA hairpins formed by CAG repeats: roles of sequence parity and trinucleotide interrupts
por: Xu, Pengning, et al.
Publicado: (2020)

Genes and pathways affected by CAG-repeat RNA-based toxicity in Drosophila
por: Shieh, Shin-Yi, et al.
Publicado: (2011)

A Structural Potential of Rare Trinucleotide Repeat Tracts in RNA
por: Magner, Dorota, et al.
Publicado: (2022)

Base excision repair of oxidative DNA damage coupled with removal of a CAG repeat hairpin attenuates trinucleotide repeat expansion
por: Xu, Meng, et al.
Publicado: (2014)

Studies on Copper and Aβ(1-16)-Induced Conformational Changes in CAG/CTG Trinucleotide Repeats Sequence
por: Govindaraju, M., et al.
Publicado: (2017)

Strand-specific effect of Rad26 and TFIIS in rescuing transcriptional arrest by CAG trinucleotide repeat slip-outs
por: Xu, Jun, et al.
Publicado: (2021)

Identification of genes in trinucleotide repeat RNA toxicity pathways in C. elegans
por: Garcia, Susana M. D. A., et al.
Publicado: (2014)

Expanded CUG Repeat RNA Induces Premature Senescence in Myotonic Dystrophy Model Cells
por: Hasuike, Yuhei, et al.
Publicado: (2022)

Fluorescence-Based Binding Characterization of Small Molecule Ligands Targeting CUG RNA Repeats
por: Chang, Zhihua, et al.
Publicado: (2022)

Neil1 is a genetic modifier of somatic and germline CAG trinucleotide repeat instability in R6/1 mice
por: Møllersen, Linda, et al.
Publicado: (2012)

A Novel Triplet-Primed PCR Assay to Detect the Full Range of Trinucleotide CAG Repeats in the Huntingtin Gene (HTT)
por: De Luca, Alessandro, et al.
Publicado: (2021)

A superfolding Spinach2 reveals the dynamic nature of trinucleotide repeat RNA
por: Strack, Rita L., et al.
Publicado: (2013)

Trinucleotide repeats in human genome and exome
por: Kozlowski, Piotr, et al.
Publicado: (2010)

Trinucleotide repeats: triggers for genomic disorders?
por: Kozlowski, Piotr, et al.
Publicado: (2010)

Trinucleotide Repeats: A Structural Perspective
por: Almeida, Bruno, et al.
Publicado: (2013)

Twisting Right to Left: A…A Mismatch in a CAG Trinucleotide Repeat Overexpansion Provokes Left-Handed Z-DNA Conformation
por: Khan, Noorain, et al.
Publicado: (2015)

Androgen receptor (AR)-CAG trinucleotide repeat length and idiopathic male infertility: a case-control trial and a meta-analysis
por: Mobasseri, Narges, et al.
Publicado: (2018)

Association of trinucleotide repeat polymorphisms CAG and GGC in exon 1 of the androgen receptor gene with male infertility: a cross-sectional study
por: ASHRAF, Mussarat, et al.
Publicado: (2020)

Biophysical mechanisms for QRS- and QTc-interval prolongation in mice with cardiac expression of expanded CUG-repeat RNA
por: Tylock, Kevin M., et al.
Publicado: (2020)

Reversible cardiac disease features in an inducible CUG repeat RNA–expressing mouse model of myotonic dystrophy
por: Rao, Ashish N., et al.
Publicado: (2021)

Structural basis for water modulating RNA duplex formation in the CUG repeats of myotonic dystrophy type 1
por: Wang, Shun-Ching, et al.
Publicado: (2023)

Mechanisms of RNA-induced toxicity in CAG repeat disorders
por: Nalavade, R, et al.
Publicado: (2013)

DNAzyme Cleavage of CAG Repeat RNA in Polyglutamine Diseases
por: Zhang, Nan, et al.
Publicado: (2021)

Development of Fluorescent Turn-On Probes for CAG-RNA Repeats
por: Lau, Matthew Ho Yan, et al.
Publicado: (2022)

Spinocerebellar ataxia type 2 in seven Korean families: CAG trinucleotide expansion and clinical characteristics.
por: Kim, J. M., et al.
Publicado: (1999)

Cannot write session to /tmp/vufind_sessions/sess_kp5d3pr2j6tks102a4tv9ubr5h